كتاب
The methylated DNA immunoprecipitation [MeDIP] to investigate the epigenetic remodeling in cell fate determination and cancer development
| العنوان: | The methylated DNA immunoprecipitation [MeDIP] to investigate the epigenetic remodeling in cell fate determination and cancer development |
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| المؤلفون: | Masciarelli, Silvia, Bellissimo, Teresa, Iosue, Ilaria, Fazi, Francesco |
| المساهمون: | Sabrina strano, Masciarelli, Silvia, Bellissimo, Teresa, Iosue, Ilaria, Fazi, Francesco |
| بيانات النشر: | Humana Press Inc. USA New York |
| سنة النشر: | 2016 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | 5-methyl-cytosine, cancer chemoprevention, chromatin immunoprecipitation, CpG island, DNA methylation, epigenetic remodeling, MeDIP |
| الوصف: | Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development. |
| نوع الوثيقة: | book part |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/isbn/978-1-4939-3190-3; info:eu-repo/semantics/altIdentifier/isbn/978-1-4939-3191-0; info:eu-repo/semantics/altIdentifier/pmid/26608290; ispartofbook:Cancer Chemoprevention methods and protocols; volume:1379; firstpage:69; lastpage:76; numberofpages:8; serie:METHODS IN MOLECULAR BIOLOGY; http://hdl.handle.net/11573/840688Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84948780941 |
| DOI: | 10.1007/978-1-4939-3191-0_6 |
| الإتاحة: | https://doi.org/10.1007/978-1-4939-3191-0_6Test http://hdl.handle.net/11573/840688Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.44567E2A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/978-1-4939-3191-0_6 |
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