دورية أكاديمية
Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming.
| العنوان: | Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming. |
|---|---|
| المؤلفون: | Wu, Shaofa, Luo, Xiaolin, Chen, Yang, Wang, Zelan, Liu, Xi, Sun, Ning, Zhao, Junyong, Luo, Wenjian, Zhang, Jiawen, Tong, Xiaoyong, Huang, Lan, Liu, Chuan, Qin, Zhexue |
| المصدر: | Redox Biol ; ISSN:2213-2317 ; Volume:73 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Endoplasmic reticulum stress, Runx2, Sodium-glucose cotransporter 2 inhibitors, Thioredoxin domain containing 5, Vascular calcification |
| الوصف: | Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging category of oral hypoglycemic drugs that have displayed marked effects on metabolic and cardiovascular diseases, including recently reported vascular medial calcification. However, the roles and underlying mechanisms of SGLT2 inhibitors in vascular calcification have not been fully elucidated. Thus, we aimed to further determine whether SGLT2 inhibitors protect against vascular calcification and to investigate the mechanisms involved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.redox.2024.103183Test; https://pubmed.ncbi.nlm.nih.gov/38759418Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127605Test/ |
| DOI: | 10.1016/j.redox.2024.103183 |
| الإتاحة: | https://doi.org/10.1016/j.redox.2024.103183Test https://pubmed.ncbi.nlm.nih.gov/38759418Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127605Test/ |
| حقوق: | Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| رقم الانضمام: | edsbas.4455C56D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.redox.2024.103183 |
|---|