دورية أكاديمية
Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study
| العنوان: | Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study |
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| المؤلفون: | Dano H., Altinay S., Arnould L., Bletard N., Colpaert C., Dedeurwaerdere F., Dessauvagie B., Duwel V., Floris G., Fox S., Gerosa C., Jaffer S., Kurpershoek E., Lacroix-Triki M., Laka A., Lambein K., MacGrogan G. M., Marchio C., Martinez D. M., Nofech-Mozes S., Peeters D., Ravarino A., Reisenbichler E., Resetkova E., Sanati S., Schelfhout A. -M., Schelfhout V., Shaaban A. M., Sinke R., Stanciu-Pop C. M., Stobbe C., van Deurzen C. H. M., Van de Vijver K., Van Rompuy A. -S., Verschuere S., Vincent-Salomon A., Wen H., Bouzin C., Galant C., Van Bockstal M. R. |
| المساهمون: | Dano H., Altinay S., Arnould L., Bletard N., Colpaert C., Dedeurwaerdere F., Dessauvagie B., Duwel V., Floris G., Fox S., Gerosa C., Jaffer S., Kurpershoek E., Lacroix-Triki M., Laka A., Lambein K., MacGrogan G.M., Marchio C., Martinez D.M., Nofech-Mozes S., Peeters D., Ravarino A., Reisenbichler E., Resetkova E., Sanati S., Schelfhout A.-M., Schelfhout V., Shaaban A.M., Sinke R., Stanciu-Pop C.M., Stobbe C., van Deurzen C.H.M., Van de Vijver K., Van Rompuy A.-S., Verschuere S., Vincent-Salomon A., Wen H., Bouzin C., Galant C., Van Bockstal M.R. |
| بيانات النشر: | NATURE PUBLISHING GROUP ELSEVIER SCIENCE INC |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | archeo, envir |
| الوصف: | Histopathological assessment of ductal carcinoma in situ, a nonobligate precursor of invasive breast cancer, is characterized by considerable interobserver variability. Previously, post hoc dichotomization of multicategorical variables was used to determine the "ideal" cutoffs for dichotomous assessment. The present international multicenter study evaluated interobserver variability among 39 pathologists who performed upfront dichotomous evaluation of 149 consecutive ductal carcinomas in situ. All pathologists independently assessed nuclear atypia, necrosis, solid ductal carcinoma in situ architecture, calcifications, stromal architecture, and lobular cancerization in one digital slide per lesion. Stromal inflammation was assessed semiquantitatively. Tumor-infiltrating lymphocytes were quantified as percentages and dichotomously assessed with a cutoff at 50%. Krippendorff's alpha (KA), Cohen's kappa and intraclass correlation coefficient were calculated for the appropriate variables. Lobular cancerization (KA = 0.396), nuclear atypia (KA = 0.422), and stromal architecture (KA = 0.450) showed the highest interobserver variability. Stromal inflammation (KA = 0.564), dichotomously assessed tumor-infiltrating lymphocytes (KA = 0.520), and comedonecrosis (KA = 0.539) showed slightly lower interobserver disagreement. Solid ductal carcinoma in situ architecture (KA = 0.602) and calcifications (KA = 0.676) presented with the lowest interobserver variability. Semiquantitative assessment of stromal inflammation resulted in a slightly higher interobserver concordance than upfront dichotomous tumor-infiltrating lymphocytes assessment (KA = 0.564 versus KA = 0.520). High stromal inflammation corresponded best with dichotomously assessed tumor-infiltrating lymphocytes when the cutoff was set at 10% (kappa = 0.881). Nevertheless, a post hoc tumor-infiltrating lymphocytes cutoff set at 20% resulted in the highest interobserver agreement (KA = 0.669). Despite upfront dichotomous evaluation, the interobserver variability remains . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/2318/1717853Test |
| الإتاحة: | http://hdl.handle.net/2318/1717853Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.443094BB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |