دورية أكاديمية
A quadriphasic mechanical model of the human dermis
| العنوان: | A quadriphasic mechanical model of the human dermis |
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| المؤلفون: | Sachs, David, Jakob, Raphael, Restivo, Gaetana, Hafner, Jürg, Lindenblatt, Nicole, Ehret, Alexander Edmund, id_orcid:0 000-0002-8740-8900, Mazza, Edoardo, id_orcid:0 000-0001-9427-4157 |
| المصدر: | Biomechanics and Modeling in Mechanobiology |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Dermis, Mechanobiology, Electrical potential, Osmotic pressure, Quadriphasic model |
| الوصف: | The present study investigates the multiphasic nature of the mechanical behavior of human dermis. Motivated by experimental observations and by consideration of its composition, a quadriphasic model of the dermis is proposed, distinguishing solid matrix components, interstitial fluid and charged constituents moving within the fluid, i.e., anions and cations. Compression and tensile experiments with and without change of osmolarity of the bath are performed to characterize the chemo-mechanical coupling in the dermis. Model parameters are determined through inverse analysis. The computations predict a dominant role of the permeability in the determination of the temporal evolution of the mechanical response of the tissue. In line with the previous studies on other tissues, the analysis shows that an ideal model based on Donnan's equilibrium overestimates the osmotic pressure in skin for the case of very dilute solutions. The quadriphasic model is applied to predict changes in dermal cell environment and therefore alterations in what is called the "mechanome," associated with skin stretch. The simulations indicate that skin deformation causes a variation in several local variables, including in particular the electric field associated with a deformation-induced non-homogeneous distribution of fixed charges. ; ISSN:1617-7959 ; ISSN:1617-7940 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/001185760600002; http://hdl.handle.net/20.500.11850/667314Test |
| DOI: | 10.3929/ethz-b-000667314 |
| الإتاحة: | https://doi.org/20.500.11850/667314Test https://doi.org/10.3929/ethz-b-000667314Test https://doi.org/10.1007/s10237-024-01827-5Test https://hdl.handle.net/20.500.11850/667314Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.43D5B275 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000667314 |
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