التفاصيل البيبلوغرافية
| العنوان: |
Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates |
| المؤلفون: |
Loukas, Alex, Gaze, Soraya, Pearson, Mark, Doolan, Denise, Felgner, Philip, Diemert, David, Mcmanus, Donald P., Driguez, Patrick, Bethony, Jeffrey |
| المصدر: |
Medicine Faculty Publications |
| بيانات النشر: |
Health Sciences Research Commons |
| سنة النشر: |
2012 |
| المجموعة: |
George Washington University: Health Sciences Research Commons (HSRC) |
| مصطلحات موضوعية: |
Genomics, Immunomics, Proteomics, Schistosomiasis, Sm-TSP-2, Transcriptomics, Vaccine |
| الوصف: |
Vaccine development for schistosomiasis has had a chequered history. Many antigens that showed initial promise in murine models dropped by the wayside and only two vaccines are currently in clinical trials. In this chapter, we discuss antigen discovery in light of the "schistosomics" revolution, with a particular focus on immunomics, and undertake some crystal ball gazing on where all this information might lead us in the near future. We then discuss the transition of neglected tropical disease vaccines towards clinical trials via a public-private partnership model, using the discovery and preclinical development of the Sm-TSP-2 schistosomiasis vaccine as a case study. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/3532Test |
| الإتاحة: |
https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/3532Test |
| رقم الانضمام: |
edsbas.43BA840F |
| قاعدة البيانات: |
BASE |
