التفاصيل البيبلوغرافية
| العنوان: |
Humanized dopamine D 4.7 receptor male mice display risk‐taking behavior and deficits of social recognition and working memory in light/dark‐dependent manner |
| المؤلفون: |
Alachkar, Amal, Phan, Alvin, Dabbous, Travis, Alhassen, Sammy, Alhassen, Wedad, Reynolds, Bryan, Rubinstein, Marcelo, Ferré, Sergi, Civelli, Olivier |
| المصدر: |
Journal of Neuroscience Research ; volume 102, issue 2 ; ISSN 0360-4012 1097-4547 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
The dopamine D 4 receptor 7‐repeat allele (D 4.7 R) has been linked with psychiatric disorders such as attention‐deficit–hyperactivity disorder, autism, and schizophrenia. However, the highly diverse study populations and often contradictory findings make it difficult to draw reliable conclusions. The D 4.7 R has the potential to explain individual differences in behavior. However, there is still a great deal of ambiguity surrounding whether it is causally connected to the etiology of psychiatric disorders. Therefore, humanized D 4.7 R mice, with the long third intracellular domain of the human D 4.7 R, may provide a valuable tool to examine the relationship between the D 4.7 R variant and specific behavioral phenotypes. We report that D 4.7 R male mice carrying the humanized D 4.7 R variant exhibit distinct behavioral features that are dependent on the light–dark cycle. The behavioral phenotype was characterized by a working memory deficit, delayed decision execution in the light phase, decreased stress and anxiety, and increased risk behavior in the dark phase. Further, D 4.7 R mice displayed impaired social recognition memory in both the light and dark phases. These findings provide insight into the potential causal relationship between the human D 4.7 R variant and specific behaviors and encourage further consideration of dopamine D 4 receptor (DRD4) ligands as novel treatments for psychiatric disorders in which D 4.7 R has been implicated. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/jnr.25299 |
| الإتاحة: |
https://doi.org/10.1002/jnr.25299Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.4340664B |
| قاعدة البيانات: |
BASE |
