دورية أكاديمية
Oxaliplatin-Related Acute Myelogenous Leukemia
| العنوان: | Oxaliplatin-Related Acute Myelogenous Leukemia |
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| المؤلفون: | Carneiro, Benedito A., Kaminer, Lynne, Eldibany, Mohammed, Sreekantaiah, Chandrika, Kaul, Karen, Locker, Gershon Y. |
| المصدر: | The Oncologist ; volume 11, issue 3, page 261-262 ; ISSN 1083-7159 1549-490X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Cancer Research, Oncology |
| الوصف: | A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen). Thirteen months later, a pelvic recurrence was diagnosed, and the patient received nine cycles of FOLFOX-6 plus bevacizumab, resulting in a clinical complete response but the development of pancytopenia. Bone marrow biopsy was consistent with therapy-related acute myelogenous leukemia. Chromosome analysis showed structural rearrangements with partial deletions of the long arms of chromosomes 5, 7, 20, and 21, as well as trisomy of chromosome 8 and losses of chromosomes 3 and 11. Induction chemotherapy led to remission, but the patient died two months later from complications of colon cancer progression. It is likely that the leukemia was related to the oxaliplatin administration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1634/theoncologist.11-3-261 |
| الإتاحة: | https://doi.org/10.1634/theoncologist.11-3-261Test https://academic.oup.com/oncolo/article-pdf/11/3/261/41850857/oncolo_11_3_261.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.42D2A7E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1634/theoncologist.11-3-261 |
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