التفاصيل البيبلوغرافية
| العنوان: |
Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination |
| المؤلفون: |
Watson, Robert A, Ye, Weiyu, Taylor, Chelsea A, Jungkurth, Elsita, Cooper, Rosalin, Tong, Orion, James, Tim, Shine, Brian, Hofer, Monika, Jenkins, Damian, Pell, Robert, Ieremia, Eleni, Jones, Stephanie, Maldonado-Perez, David, Roberts, Ian S D, Coupe, Nicholas, Middleton, Mark R, Payne, Miranda J, Fairfax, Benjamin P |
| المساهمون: |
Oxford Biomedical Research, Oxford CRUK Cancer Centre, Wellcome Trust, National Institute for Health Research, Balliol Jowett Society, Cancer Research UK, Engineering and Physical Sciences Research Council |
| المصدر: |
Journal for ImmunoTherapy of Cancer ; volume 12, issue 4, page e008151 ; ISSN 2051-1426 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2024 |
| الوصف: |
We describe three cases of critical acute myositis with myocarditis occurring within 22 days of each other at a single institution, all within 1 month of receiving the initial cycle of the anti-PD-1 drug pembrolizumab. Analysis of T cell receptor repertoires from peripheral blood and tissues revealed a high degree of clonal expansion and public clones between cases, with several T cell clones expanded within the skeletal muscle putatively recognizing viral epitopes. All patients had recently received a COVID-19 mRNA booster vaccine prior to treatment and were positive for SARS-CoV2 Spike antibody. In conclusion, we report a series of unusually severe myositis and myocarditis following PD-1 blockade and the COVID-19 mRNA vaccination. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/jitc-2023-008151 |
| الإتاحة: |
https://doi.org/10.1136/jitc-2023-008151Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.42364540 |
| قاعدة البيانات: |
BASE |
