دورية أكاديمية
The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
| العنوان: | The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease |
|---|---|
| المؤلفون: | Penna Martinez, Marissa, Ramos-Lopez, Elizabeth, Robbers, Inka, Kahles, Heinrich, Hahner, Stefanie, Willenberg, Holger S., Reisch, Nicole, Seidl, Christian, Segni, Maria, Badenhoop, Klaus |
| سنة النشر: | 2009 |
| المجموعة: | Publication Server of Goethe University Frankfurt am Main |
| مصطلحات موضوعية: | ddc:610 |
| الوصف: | Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n=258), Hashimoto's thyroiditis (HT,n=106), Addison's disease (AD,n=195) and healthy controls (HC,n=227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results:No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD:TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2:for GD and HT, DQ2/DQ8:for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%;p=0.05;corrected p [pc]=0.1). However, these associations did not remain ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7362Test; urn:nbn:de:hebis:30-73027; https://nbn-resolving.org/urn:nbn:de:hebis:30-73027Test; https://doi.org/10.1186/1471-2350-10-126Test; http://publikationen.ub.uni-frankfurt.de/files/7362/1471_2350_10_126.pdfTest |
| DOI: | 10.1186/1471-2350-10-126 |
| الإتاحة: | https://doi.org/10.1186/1471-2350-10-126Test http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7362Test https://nbn-resolving.org/urn:nbn:de:hebis:30-73027Test http://publikationen.ub.uni-frankfurt.de/files/7362/1471_2350_10_126.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by/2.0/de/deed.deTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.42158222 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1471-2350-10-126 |
|---|