دورية أكاديمية
IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke
| العنوان: | IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke |
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| المؤلفون: | Weihua Wu, Zhaoli Luo, Danmin Shen, Ting Lan, Zhongnan Xiao, Meng Liu, Liye Hu, Tingting Sun, Yamei Wang, Jian-Nan Zhang, Chenguang Zhang, Peipei Wang, Yabin Lu, Fei Yang, Qian Li |
| المصدر: | Redox Biology, Vol 69, Iss , Pp 102982- (2024) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 1481 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Interleukin-10, Oligodendrocyte progenitor cells, Lipid reactive oxygen species, Ferroptosis, Intracerebral hemorrhagic stroke, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Accumulation of reactive oxygen species (ROS), especially on lipids, induces massive cell death in neurons and oligodendrocyte progenitor cells (OPCs) and causes severe neurologic deficits post stroke. While small compounds, such as deferoxamine, lipostatin-1, and ferrostatin-1, have been shown to be effective in reducing lipid ROS, the mechanisms by which endogenously protective molecules act against lipid ROS accumulation and subsequent cell death are still unclear, especially in OPCs, which are critical for maintaining white matter integrity and improving long-term outcomes after stroke. Here, using mouse primary OPC cultures, we demonstrate that interleukin-10 (IL-10), a cytokine playing roles in reducing neuroinflammation and promoting hematoma clearance, significantly reduced hemorrhage-induced lipid ROS accumulation and subsequent ferroptosis in OPCs. Mechanistically, IL-10 activated the IL-10R/STAT3 signaling pathway and upregulated the DLK1/AMPK/ACC axis. Subsequently, IL-10 reprogrammed lipid metabolism and reduced lipid ROS accumulation. In addition, in an autologous blood injection intracerebral hemorrhagic stroke (ICH) mouse model, deficiency of the endogenous Il-10, specific knocking out Il10r or Dlk1 in OPCs, or administration of ACC inhibitor was associated with increased OPC cell death, demyelination, axonal sprouting, and the cognitive deficits during the chronic phase of ICH and vice versa. These data suggest that IL-10 protects against OPC loss and white matter injury by reducing lipid ROS, supporting further development of potential clinical applications to benefit patients with stroke and related disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2213-2317 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S221323172300383XTest; https://doaj.org/toc/2213-2317Test; https://doaj.org/article/20063bd3e9bc48cd87b16294cfa5c5a1Test |
| DOI: | 10.1016/j.redox.2023.102982 |
| الإتاحة: | https://doi.org/10.1016/j.redox.2023.102982Test https://doaj.org/article/20063bd3e9bc48cd87b16294cfa5c5a1Test |
| رقم الانضمام: | edsbas.4215612 |
| قاعدة البيانات: | BASE |
| تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2023.102982 |