التفاصيل البيبلوغرافية
| العنوان: |
The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes |
| المؤلفون: |
Nabrdalik-Leśniak, Diana, Nabrdalik, Katarzyna, Irlik, Krzysztof, Janota, Oliwia, Kwiendacz, Hanna, Szromek-Białek, Paulina, Maziarz, Mirosław, Stompór, Tomasz, Gumprecht, Janusz, Lip, Gregory Y. H. |
| المصدر: |
Endokrynologia Polska; Vol 74, No 4 (2023); 349-362 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2023 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
sodium-glucose cotransporter 2 inhibitors, oxidative stress, diabetes mellitus, chronic kidney disease, heart failure |
| الوصف: |
There is increasing interest in sodium-glucose cotransporter 2 inhibitors (SGLT2i) as not only a new oral glucose-lowering drug class but also one with cardio- and nephroprotective potential. Understanding the underlying mechanisms is therefore of great interest, and postulated benefits have included increased natriuresis, lower blood pressure, increased haematocrit, enhanced cardiac fatty acid utilization, reduced low-grade inflammation, and decreased oxidative stress. In particular, redox homeostasis seems to be crucial in the pathogenesis of heart and kidney disease in diabetes, and there is accumulating evidence that SGLT2i have beneficial effects in this perspective. In this review, we aimed to summarize the potential mechanisms of the influence of SGLT2i on oxidative stress parameters in animal and human studies, with a special focus on heart failure and chronic kidney disease in diabetes mellitus. |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf; text/html |
| اللغة: |
English |
| العلاقة: |
https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2023.0039Test |
| DOI: |
10.5603/EP.a2023.0039 |
| الإتاحة: |
https://doi.org/10.5603/EP.a2023.0039Test
https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2023.0039Test |
| حقوق: |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the copyright holder, i.e. Polish Society of Endocrinology, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent. ; Przesyłając manuskrypt wraz z ilustracjami i tabelami, Autorzy automatycznie i nieodpłatnie przenoszą na Polskie Towarzystwo Endokrynologiczne i "Endokrynologię Polską" wszelkie prawa autorskie do wydawania oraz rozpowszechniania nadesłanych materiałów we wszystkich znanych formach i na wszystkich znanych polach eksploatacji, bez ograniczeń terytorialnych językowych, pod warunkiem że materiały te zostaną zaakceptowane do publikacji. Publikacja w całości ani w żadna jej część nie może być powielana ani upowszechniana w jakikolwiek mechaniczny lub elektroniczny sposób bez pisemnej zgody Redaktora Naczelnego. |
| رقم الانضمام: |
edsbas.4204C873 |
| قاعدة البيانات: |
BASE |
