التفاصيل البيبلوغرافية
| العنوان: |
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial |
| المؤلفون: |
Coombs, J.H., Bloom, B.J., Breedveld, F.C., Fletcher, M.P., Gruben, D., Kremer, J.M., Burgos-Vargas, R., Wilkinson, B., Zerbini, C.A.F., Zwillich, S.H. |
| المصدر: |
Annals of the Rheumatic Diseases |
| سنة النشر: |
2010 |
| المجموعة: |
Leiden Repository (Leiden University) |
| مصطلحات موضوعية: |
quality-of-life combination therapy monoclonal-antibody reported outcomes methotrexate etanercept adalimumab efficacy safety |
| الوصف: |
Objectives: To determine the efficacy of CP-690,550 in improving pain, function and health status in patients with moderate to severe active rheumatoid arthritis (RA) and an inadequate response to methotrexate or a tumour necrosis factor a inhibitor. Methods: Patients were randomised equally to placebo, CP-690,550 5, 15 or 30 mg twice daily for 6 weeks, with 6 weeks' follow-up. The patient's assessment of arthritis pain (pain), patient's assessment of disease activity, Health Assessment Questionnaire-Disability Index (HAQ-DI) and Short Form-36 (SF-36) were recorded. Results: At week 6, significantly more patients in the CP-690,550 5, 15 and 30 mg twice-daily groups experienced a 50% improvement in pain compared with placebo (44%, 66%, 78% and 14%, respectively), clinically meaningful reductions in HAQ-DI (>= 0.3 units) (57%, 75%, 76% and 36%, respectively) and clinically meaningful improvements in SF-36 domains and physical and mental components. Conclusions: CP-690,550 was efficacious in improving the pain, function and health status of patients with RA, from week 1 to week 6. ; Pathophysiology and treatment of rheumatic diseases |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
lumc-id: 5605810; https://hdl.handle.net/1887/111426Test |
| الإتاحة: |
https://hdl.handle.net/1887/111426Test |
| رقم الانضمام: |
edsbas.41FC3BF4 |
| قاعدة البيانات: |
BASE |
