دورية أكاديمية
Potential Differences in the Cardiometabolic Risk Profile of Patients with Psoriatic Disease according to Their HLA-C∗06 Status
| العنوان: | Potential Differences in the Cardiometabolic Risk Profile of Patients with Psoriatic Disease according to Their HLA-C∗06 Status |
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| المؤلفون: | Rubén Queiro, Pablo Coto-Segura, Ignacio Braña, Marina Pino, Stefanie Burger |
| المصدر: | BioMed Research International, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | The human leukocyte antigen-C∗06 (HLA-C∗06, formerly HLA-Cw6) is the main genetic biomarker in psoriatic disease. It has been related to several phenotypic traits in psoriatic disease, but its role in relation to cardiometabolic comorbidities is unknown at present. Here, we analyze the potential connections between this biomarker and the cardiometabolic profile of these patients. We carried out a cross-sectional observational study including 400 patients recruited at a single university hospital. Clinical and classical cardiometabolic factors were compared between HLA-C∗06-positive and HLA-C∗06-negative individuals (OR with 95% CI). Multivariate regression analyses were carried out to check for disease traits associated with different cardiometabolic risk factors. The study population included 215 men (53.8%) and 185 women (46.2%), mean age of 46±15 years, and an average disease evolution of 17±12.6 years. Ninety-three (23.3%) patients met CASPAR criteria for psoriatic arthritis. HLA-C∗06 carriers (n: 160, 40%) showed an earlier age at disease onset, psoriasis family history, and more severe skin disease (type I disease). After correcting for age, sex, and disease duration, they also showed less hypertension (13.8% vs. 24.2%, OR 0.7 (95% CI: 0.42-0.78), p=0.025), lower waist circumference (94.4±13.7 vs. 98.3±13.8 cm), and lower BMI (27±4.4 vs. 28.1±4.8, p<0.05). We confirmed the well-known association between HLA-C∗06 and type I psoriatic disease. As a novel finding, patients carrying HLA-C∗06 showed a better cardiometabolic profile. In any case, these findings need further confirmation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6141 |
| العلاقة: | http://dx.doi.org/10.1155/2022/1451193Test; https://doaj.org/toc/2314-6141Test; https://doaj.org/article/0a7a2468fcf34f438378b494b3ac64eaTest |
| DOI: | 10.1155/2022/1451193 |
| الإتاحة: | https://doi.org/10.1155/2022/1451193Test https://doaj.org/article/0a7a2468fcf34f438378b494b3ac64eaTest |
| رقم الانضمام: | edsbas.4153760C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146141 |
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| DOI: | 10.1155/2022/1451193 |