دورية أكاديمية
Formation of vascular-like structures using a chemotaxis-driven multiphase model
| العنوان: | Formation of vascular-like structures using a chemotaxis-driven multiphase model |
|---|---|
| المؤلفون: | Al-Badri, Georgina, Phillips, James B, Shipley, Rebecca J, Ovenden, Nicholas C |
| المصدر: | Mathematical Biosciences , 372 , Article 109183. (2024) |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2024 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Chemotaxis, Multiphase modelling, Tissue engineering, Vasculogenesis |
| الوصف: | We propose a continuum model for pattern formation, based on the multiphase model framework, to explore in vitro cell patterning within an extracellular matrix. We demonstrate that, within this framework, chemotaxis-driven cell migration can lead to the formation of cell clusters and vascular-like structures in 1D and 2D respectively. The influence on pattern formation of additional mechanisms commonly included in multiphase tissue models, including cell-matrix traction, contact inhibition, and cell-cell aggregation, are also investigated. Using sensitivity analysis, the relative impact of each model parameter on the simulation outcomes is assessed to identify the key parameters involved. Chemoattractant-matrix binding is further included, motivated by previous experimental studies, and found to reduce the spatial scale of patterning to within a biologically plausible range for capillary structures. Key findings from the in-depth parameter analysis of the 1D models, both with and without chemoattractant-matrix binding, are demonstrated to translate well to the 2D model, obtaining vascular-like cell patterning for multiple parameter regimes. Overall, we demonstrate a biologically-motivated multiphase model capable of generating long-term pattern formation on a biologically plausible spatial scale both in 1D and 2D, with applications for modelling in vitro vascular network formation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10190598/1/1-s2.0-S0025556424000439-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10190598Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10190598/1/1-s2.0-S0025556424000439-main.pdfTest https://discovery.ucl.ac.uk/id/eprint/10190598Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.4143F7EF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |