التفاصيل البيبلوغرافية
| العنوان: |
Integrative Clinical, Hormonal and Molecular Data associate with Invasiveness in Acromegaly: REMAH Study |
| المؤلفون: |
Sampedro-Nuñez, Miguel, Herrera-Martínez, Aura Dulcinea, Ibáñez-Costa, Alejandro, Rivero-Cortés, Esther, Venegas, Eva, Robledo, Mercedes, Martínez-Hernández, Rebeca, García-Martínez, Araceli, Gil, Joan, Jordà, Mireia, López-Fernández, Judith, Gavilán, Inmaculada, Maraver, Silvia, Marqués-Pamies, Montserrat, Cámara, Rosa, Fajardo-Montañana, Carmen, Valassi, Elena, Dios, Elena, Aulinas, Anna, Biagetti, Betina, Álvarez Escola, Cristina, Araujo-Castro, Marta, Blanco, Concepción, de Miguel, Paz, Villar-Taibo, Rocío, Álvarez, Clara V, Gaztambide, Sonia, Webb, Susan M, Castaño, Luis, Bernabéu, Ignacio, Picó, Antonio, Gálvez, María-Ángeles, Soto-Moreno, Alfonso, Puig-Domingo, Manel, Castaño, Justo P, Marazuela, Mónica, Luque, Raúl M, Adrados, Magdalena, Flores, Pedro Martínez, Leví, Ana María Ramos, Serrano-Somavilla, Ana, Díez, Juan José, Villanueva, Mercedes García, Iglesias, Pedro, Berrocal, Víctor Rodríguez, Gutiérrez, Esperanza Aguillo, Bances, Luciano, Calvo Gracia, Fernando L, Comunas, Fernando, López, Iván Quiroga |
| المصدر: |
European Journal of Endocrinology ; ISSN 0804-4643 1479-683X |
| بيانات النشر: |
Oxford University Press (OUP) |
| سنة النشر: |
2024 |
| الوصف: |
Introduction Growth-hormone (GH)-secreting pituitary-tumors (GHomas) are the most common acromegaly cause. At diagnosis, most of them are macroadenomas, and up to 56% display cavernous sinus invasion. Biomarkers assessment associated with tumor-growth and invasion are important to optimize their management. Objectives To identify clinical/hormonal/molecular-biomarkers associated with tumor-size and invasiveness in GHomas, and to analyze the influence of pre-treatment with somatostatin-analogs or dopamine-agonists in key molecular biomarkers expression. Methods Clinical/analytical/radiological-variables were evaluated in 192 patients from the REMAH-study (ambispective multicenter post-surgery study of the Spanish Society of Endocrinology and Nutrition). Expression of somatostatin/ghrelin/dopamine-systems components, and key pituitary/proliferation-markers were evaluated in GHomas after the first surgery. Univariate/multivariate regression studies were performed to identify association between variables. Results 80% of patients harbor macroadenomas (63.8% with extrasellar-growth). Associations between larger and more invasive GHomas with younger age, visual-abnormalities, higher IGF1-levels, extrasellar/suprasellar-growth and/or cavernous-sinus invasion were found. Higher GH1 and lower PRL/POMC/CGA/AVPR1B/DRD2T/DRD2L expression levels (p<0.05) were associated to tumor invasiveness. LASSO´s penalized regression identified combinations of clinical and molecular features with AUCs between 0.67-0.82. Preoperative therapy with dopamine-agonist or somatostatin-analogs did not alter the expression of any of the markers analyzed except for DRD1/AVPR1B (up-regulated with dopamine-agonist), and FSHB/CRHR1 (down-regulated with somatostatin-analogs). Conclusions A specific combination of clinical/analytical/molecular variables was found to be associated with tumor invasiveness and growth capacity in GHomas. Pre-treatment with first-line drugs for acromegaly did not significantly modify the expression of the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1093/ejendo/lvae045 |
| DOI: |
10.1093/ejendo/lvae045/57399930/lvae045.pdf |
| الإتاحة: |
https://doi.org/10.1093/ejendo/lvae045Test |
| حقوق: |
https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.41355C6A |
| قاعدة البيانات: |
BASE |
