مراجعة
A comprehensive review about the utilization of immune checkpoint inhibitors and combination therapy in hepatocellular carcinoma: an updated review
| العنوان: | A comprehensive review about the utilization of immune checkpoint inhibitors and combination therapy in hepatocellular carcinoma: an updated review |
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| المؤلفون: | Adili, Ali, Ghoreishizadeh, Shadi, Shomali, Navid, Hasani, Sadegh Abaei, Sharafi, Faezeh, Alesaeidi, Samira, Kahrizi, Mohammad Saeed |
| بيانات النشر: | Bmc |
| سنة النشر: | 2022 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Hepatocellular carcinoma, T-Cells, Blockade, Ctla-4, Immune checkpoint inhibitors, Combination therapy, Acquired-Resistance, Tigit, Antitumor, Tim-3, Lag-3, Tremelimumab, Mechanisms |
| الوصف: | A pharmacological class known as immune checkpoint inhibitors (ICIs) has been developed as a potential treatment option for various malignancies, including HCC. In HCC, ICIs have demonstrated clinically significant advantages as monotherapy or combination therapy. ICIs that target programmed cell death protein 1 (PD-1) and programmed cell death protein ligand 1 (PD-L1), as well as cytotoxic T lymphocyte antigen 4 (CTLA-4), have made significant advances in cancer treatment. In hepatocellular carcinoma (HCC), several ICIs are being tested in clinical trials, and the area is quickly developing. As immunotherapy-related adverse events (irAEs) linked with ICI therapy expands and gain worldwide access, up-to-date management guidelines become crucial to the safety profile of ICIs. This review aims to describe the evidence for ICIs in treating HCC, emphasizing the use of combination ICIs. |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 1475-2867 |
| العلاقة: | Cancer Cell International; Diğer; https://hdl.handle.net/11454/77817Test; https://doi.org/10.1186/s12935-022-02682-zTest; Kahrizi, Mohammad saeed/0000-0002-8076-2413; 22 |
| DOI: | 10.1186/s12935-022-02682-z |
| الإتاحة: | https://doi.org/10.1186/s12935-022-02682-zTest https://hdl.handle.net/11454/77817Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.4132A06A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752867 |
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| DOI: | 10.1186/s12935-022-02682-z |