دورية أكاديمية
Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy
| العنوان: | Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy |
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| المؤلفون: | Porcari, Aldostefano, Fontana, Marianna, Canepa, Marco, Biagini, Elena, Cappelli, Francesco, Gagliardi, Christian, Longhi, Simone, Pagura, Linda, Tini, Giacomo, Dore, Franca, Bonfiglioli, Rachele, Bauckneht, Matteo, Miceli, Alberto, Girardi, Francesca, Martini, Anna Lisa, Barbati, Giulia, Costanzo, Egidio Natalino, Caponetti, Angelo Giuseppe, Paccagnella, Andrea, Sguazzotti, Maurizio, La Malfa, Giovanni, Zampieri, Mattia, Sciagrà, Roberto, Perfetto, Federico, Rowczenio, Dorota, Gilbertson, Janet, Hutt, David F, Hawkins, Philip N, Rapezzi, Claudio, Merlo, Marco, Sinagra, Gianfranco, Gillmore, Julian D |
| المصدر: | Circulation (2024) (In press). |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | cardiomyopathies, heart ventricles, tomography, emission-computed, single-photon |
| الوصف: | BACKGROUND: The extent of myocardial bone tracer uptake with technetium pyrophosphate, hydroxymethylene diphosphonate, and 3,3-diphosphono-1,2-propanodicarboxylate in transthyretin amyloid cardiomyopathy (ATTR-CM) might reflect cardiac amyloid burden and be associated with outcome. METHODS: Consecutive patients with ATTR-CM who underwent diagnostic bone tracer scintigraphy with acquisition of whole-body planar and cardiac single-photon emission computed tomography (SPECT) images from the National Amyloidosis Centre and 4 Italian centers were included. Cardiac uptake was defined according to the Perugini classification: 0=absent cardiac uptake; 1=mild uptake less than bone; 2=moderate uptake equal to bone; and 3=high uptake greater than bone. Extent of right ventricular (RV) uptake was defined as focal (basal segment of the RV free wall only) or diffuse (extending beyond basal segment) on the basis of SPECT imaging. The primary outcome was all-cause mortality. RESULTS: Among 1422 patients with ATTR-CM, RV uptake accompanying left ventricular uptake was identified by SPECT imaging in 100% of cases at diagnosis. Median follow-up in the whole cohort was 34 months (interquartile range, 21 to 50 months), and 494 patients died. By Kaplan-Meier analysis, diffuse RV uptake on SPECT imaging (n=936) was associated with higher all-cause mortality compared with focal (n=486) RV uptake (77.9% versus 22.1%; P<0.001), whereas Perugini grade was not associated with survival (P=0.27 in grade 2 versus grade 3). On multivariable analysis, after adjustment for age at diagnosis (hazard ratio [HR], 1.03 [95% CI, 1.02-1.04]; P<0.001), presence of the p.(V142I) TTR variant (HR, 1.42 [95% CI, 1.20-1.81]; P=0.004), National Amyloidosis Centre stage (each category, P<0.001), stroke volume index (HR, 0.99 [95% CI, 0.97-0.99]; P=0.043), E/e' (HR, 1.02 [95% CI, 1.007-1.03]; P=0.004), right atrial area index (HR, 1.05 [95% CI, 1.02-1.08]; P=0.001), and left ventricular global longitudinal strain (HR, 1.06 [95% CI, 1.03-1.09]; ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10187901/1/porcari-et-al-2024-clinical-and-prognostic-implications-of-right-ventricular-uptake-on-bone-scintigraphy-in.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10187901Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10187901/1/porcari-et-al-2024-clinical-and-prognostic-implications-of-right-ventricular-uptake-on-bone-scintigraphy-in.pdfTest https://discovery.ucl.ac.uk/id/eprint/10187901Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.40F01C6F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |