دورية أكاديمية
Hematogenous osteomyelitis in childhood can relapse many years later into adulthood: A retrospective multicentric cohort study in France
| العنوان: | Hematogenous osteomyelitis in childhood can relapse many years later into adulthood: A retrospective multicentric cohort study in France |
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| المؤلفون: | Clerc, Axelle, Zeller, Valérie, Marmor, Simon, Senneville, Eric, Marchou, Bruno, Laurent, Frédéric, Lucht, Frédéric, Desplaces, Nicole, Lustig, Sebastien, Chidiac, Christian, Ferry, Tristan |
| المساهمون: | Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hôpital de la Croix-Rousse CHU - HCL, Hospices Civils de Lyon (HCL), Groupe Hospitalier Diaconesses Croix Saint-Simon, Centre Hospitalier Gustave Dron Tourcoing, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Service Maladies infectieuses et tropicales CHU Toulouse, Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Service de Maladies Infectieuses et Tropicales Hôpital de la Croix-Rousse - HCL, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) |
| المصدر: | ISSN: 0025-7974. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2020 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | adulthood, hematogenous osteomyelitis, relapse, Staphylococcus aureus, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | To describe the epidemiological, clinical, laboratory, and radiological features and the management of adult patients who experienced a relapse between 2003 and 2015 of an acute hematogenous osteomyelitis acquired in childhood.A retrospective multicentric cohort study was conducted in 5 centers in France. Thirty-seven patients were included. The median age was 40 years (28-56), and 26 (70%) were male. The first site of infection was the distal femur (n=23, 62%). The median time between the osteomyelitis in childhood and the relapse in adulthood was 26 years (13-45). Thirty-four (92%) patients reported inflammatory local clinical manifestations, 17 (46%) draining fistula, 10 (27%) fever. Most patients had intramedullary gadolinium deposition (with or without abscess) on magnetic resonance imaging. Most relapses were monomicrobial infections (82%). Staphylococcus aureus was the most commonly found microorganism (82%), expressing a small colony variant phenotype in 3 cases. Most patients (97%) had a surgical treatment, and the median duration of antibiotics for the relapse was 12 weeks. All patients had a favorable outcome, no patient died and no further relapse occurred. We count 2 femoral fractures on osteotomy site.Osteomyelitis in childhood can relapse later in adulthood, especially in patients with lack of care during the initial episode. Osteotomy and prolonged antimicrobial therapy are required for clinical remission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03150828; https://hal.science/hal-03150828Test; https://hal.science/hal-03150828/documentTest; https://hal.science/hal-03150828/file/ris00001804.pdfTest |
| DOI: | 10.1097/MD.0000000000019617 |
| الإتاحة: | https://doi.org/10.1097/MD.0000000000019617Test https://hal.science/hal-03150828Test https://hal.science/hal-03150828/documentTest https://hal.science/hal-03150828/file/ris00001804.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.40BF5991 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/MD.0000000000019617 |
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