التفاصيل البيبلوغرافية
| العنوان: |
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients |
| المؤلفون: |
Bruno, Raphael Romano, Wernly, Bernhard, Flaatten, Hans, Fjølner, Jesper, Artigas, Antonio, Pinto, Bernardo Bollen, Schefold, Joerg C, Binnebössel, Stephan, Baldia, Philipp Heinrich, Kelm, Malte, Beil, Michael, Sigal, Sivri, Heerden, Peter Vernon Van, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Zafeiridis, Tilemachos, Wollborn, Jakob, Banzo, Maria José Arche, Fuest, Kristina, Marsh, Brian, Andersen, Finn H, Moreno, Rui, Leaver, Susannah, Boumendil, Ariane, Lange, Dylan W De, Guidet, Bertrand, Jung, Christian, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Serck, Nicolas, Dewaele, Elisabeth, Chapeta, Edwin, Brix, Helene, Brushoej, Jens, Kumar, Pritpal, Nedergaard, Helene Korvenius, Johnsen, Tim Koch, Bundesen, Camilla, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Innes, Richard, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Abusayed, Mohammed Abdelshafy, Humphreys, Sally, Collins, Amy, Aujayeb, Avinash, Khaliq, Waqas, Habib, Ayman Abdelmawgoad, Azab, Mohammed A, Wassim, Kyrillos, Elgazzar, Yumna A, Salah, Rehab, Abosheaishaa, Hazem Maarouf, Mohamed, Aliae a R Hussein, Azzam, Ahmed Y, Tharwat, Samar, Ali, Yasmin Khairy Nasreldin Mohamed, Elmandouh, Omar, Galal, Islam, Abu-Elfatth, Ahmed, Motawea, Karam, Elbahnasawy, Mohammad, Shehata, Mostafa, Elbahnasawy, Mohamed, Tayeb, Mostafa, Osman, Nermin, Abdel-Elsalam, Wafaa, Hussein, Aliae Mohamed, Aldhalia, Amer, Galbois, Arnaud, Charron, Cyril, Berlemont, Caroline Hauw, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Mentec, Hervé, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Chousterman, Benjamin Glenn, Dépret, François, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Ferre, Alexis, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Vettoretti, Lucie, Thevenin, Didier, Schaller, Stefan, Kurt, Muhammed, Faltlhauser, Andreas, Meyer, Christian, Milovanovic, Milena, Lutz, Matthias, Shala, Gonxhe, Haake, Hendrik, Randerath, Winfried, Kunstein, Anselm, Meybohm, Patrick, Steiner, Stephan, Barth, Eberhard, Poerner, Tudor, Simon, Philipp, Lorenz, Marco, Dindane, Zouhir, Kuhn, Karl Friedrich, Welte, Martin, Voigt, Ingo, Kabitz, Hans-Joachim, Goebel, Ulrich, Stoll, Sandra Emily, Kindgen-Milles, Detlef, Dubler, Simon, Schuster, Michael, Papadogoulas, Antonios, Mulita, Francesk, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Kondili, Eumorfia, Andrianopoulos, Ioannis, Gurjar, Mohan, Mahmoodpoor, Ata, Hussein, Rand, Al-Juaifari, Maytham Aqeel, Karantenachy, Abdullah Khudhur Ahmed, Sviri, Sigal, Elsaka, Ahmed, Comellini, Vittoria, Al-Ali, Farah, Almani, Sari, Khamees, Almu' Atasim, Al-Shami, Khayry, Din, Ibrahim Salah El, Abubaker, Taha, Ahmed, Hazem, Rabha, Ahmed, Alhadi, Abdulmueti, Emhamed, Marwa, Abdeewi, Saedah, Abusalama, Abdurraouf, Huwaysh, Mohammed, Alghati, Esraa Abdalqader, Ghannam, Abdelilah, Namendys-Sylva, Silvio A, Groenendijk, Martijn, Evers, Mirjam, Lelyveld-Haas, Lenneke Van, Meynaar, Iwan, Cornet, Alexander Daniel, Zegers, Marieke, Dieperink, Willem, Lange, Dylan De, Dormans, Tom, Hahn, Michael, Sjøbøe, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Romundstad, Luis, Massoud, John George Grace, Khan, Aamir Ghafoor, Al-Qasrawi, Shahd, Amro, Sarah, Kluzik, Anna, Zatorski, Paweł, Drygalski, Tomasz, Klimkiewicz, Jakub, Solek-Pastuszka, Joanna, Onichimowski, Dariusz, Czuczwar, Miroslaw, Gawda, Ryszard, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Oliveira, Ana Isabel Pinho, Assis, Rui, Santos, Maria de Lurdes Campos, Santos, Henrique, Cardoso, Filipe Sousa, Gordinho, André, Grintescu, Ioana Marina, Tomescu, Dana, Badawy, Mohamed Raafat, Banzo, M José Arche, Zalba-Etayo, Begoña, Cubero, Patricia Jimeno, Priego, Jesús, Gomà, Gemma, Tomasa-Irriguible, Teresa Maria, Sancho, Susana, Ferreira, Aida Fernández, Vázquez, Eric Mayor, Mira, Ángela Prado, Ibarz, Mercedes, Iglesias, David, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, Aldecoa, Cesar, Perez-Torres, David, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, Gopegui, Pablo Ruiz De, Saleh, Mahmoud, Hilles, Momin Majed Yousuf, Abualqumboz, Enas M Y, Ben-Hamouda, Nawfel, Roberti, Andrea, Fleury, Yvan, Abidi, Nour, Chau, Ivan, Dullenkopf, Alexander, Chaaban, Mohammad Karam, Shebani, Mohammed Mouaz, Hmaideh, Ahmad, Shaher, Aymen, Sahin, Ayca Sultan, Saracoglu, Kemal Tolga, Al-Sadawi, Mohammed, Pugh, Richard, Smuts, Sara, Al-Saban, Rafat Ameen Mohammed |
| المساهمون: |
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie |
| المصدر: |
ISSN: 2110-5820 ; Annals of Intensive Care ; https://u-picardie.hal.science/hal-03922309Test ; Annals of Intensive Care, 2021, 11 (1), pp.128. ⟨10.1186/s13613-021-00911-8⟩. |
| بيانات النشر: |
HAL CCSD
SpringerOpen |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
COVID-19, [SDV]Life Sciences [q-bio] |
| الوصف: |
International audience ; Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have been mostly affected during the initial surge in 2020.Methods: This prospective international observation study (The COVIP study) recruited patients aged 70 years or older (ClinicalTrials.gov ID: NCT04321265) admitted to an intensive care unit (ICU) with COVID-19 disease from March 2020 to February 2021. In addition to serial lactate values (arterial blood gas analysis), we recorded several parameters, including SOFA score, ICU procedures, limitation of care, ICU- and 3-month mortality. A lactate concentration ≥ 2.0 mmol/L on the day of ICU admission (baseline) was defined as abnormal. The primary outcome was ICU-mortality. The secondary outcomes 30-day and 3-month mortality.Results: In total, data from 2860 patients were analyzed. In most patients (68%), serum lactate was lower than 2 mmol/L. Elevated baseline serum lactate was associated with significantly higher ICU- and 3-month mortality (53% vs. 43%, and 71% vs. 57%, respectively, p < 0.001). In the multivariable analysis, the maximum lactate concentration on day 1 was independently associated with ICU mortality (aOR 1.06 95% CI 1.02-1.11; p = 0.007), 30-day mortality (aOR 1.07 95% CI 1.02-1.13; p = 0.005) and 3-month mortality (aOR 1.15 95% CI 1.08-1.24; p < 0.001) after adjustment for age, gender, SOFA score, and frailty. In 826 patients with baseline lactate ≥ 2 mmol/L sufficient data to calculate the difference between maximal levels on days 1 and 2 (∆ serum lactate) were available. A decreasing lactate concentration over time was inversely associated with ICU mortality after multivariate adjustment for SOFA score, age, Clinical Frailty Scale, and gender (aOR 0.60 95% CI 0.42-0.85; p = 0.004).Conclusion: In critically ill old intensive care patients suffering from COVID-19, lactate and its kinetics are ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
hal-03922309; https://u-picardie.hal.science/hal-03922309Test |
| DOI: |
10.1186/s13613-021-00911-8 |
| الإتاحة: |
https://doi.org/10.1186/s13613-021-00911-8Test
https://u-picardie.hal.science/hal-03922309Test |
| رقم الانضمام: |
edsbas.40BD6830 |
| قاعدة البيانات: |
BASE |
