دورية أكاديمية
The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum
| العنوان: | The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum |
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| المؤلفون: | Banning, Leonie C.P., Ramakers, Inez H.G.B., Köhler, Sebastian, Bron, Esther E., Verhey, Frans R.J., de Deyn, Peter Paul, Claassen, Jurgen A.H.R., Koek, Huiberdina L., Middelkoop, Huub A.M., van der Flier, Wiesje M., van der Lugt, Aad, Aalten, Pauline |
| المصدر: | Banning , L C P , Ramakers , I H G B , Köhler , S , Bron , E E , Verhey , F R J , de Deyn , P P , Claassen , J A H R , Koek , H L , Middelkoop , H A M , van der Flier , W M , van der Lugt , A , Aalten , P , The Alzheimer's Disease Neuroimaging Initiative & Parelsnoer Institute Neurodegenerative Diseases study group 2020 , ' The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum ' , American .... |
| سنة النشر: | 2020 |
| الوصف: | Objective: To investigate the relationship between Alzheimer's disease biomarkers and neuropsychiatric symptoms. Methods: Data from two large cohort studies, the Dutch Parelsnoer Institute – Neurodegenerative Diseases and the Alzheimer's Disease Neuroimaging Initiative was used, including subjects with subjective cognitive decline (N = 650), mild cognitive impairment (N = 887), and Alzheimer's disease dementia (N = 626). Cerebrospinal fluid (CSF) levels of Aβ 42 , t-tau, p-tau, and hippocampal volume were associated with neuropsychiatric symptoms (measured with the Neuropsychiatric Inventory) using multiple logistic regression analyses. The effect of the Mini-Mental State Examination (as proxy for cognitive functioning) on these relationships was assessed with mediation analyses. Results: Alzheimer's disease biomarkers were not associated with depression, agitation, irritability, and sleep disturbances. Lower levels of CSF Aβ 42 , higher levels of t- and p-tau were associated with presence of anxiety. Lower levels of CSF Aβ 42 and smaller hippocampal volumes were associated with presence of apathy. All associations were mediated by cognitive functioning. Conclusion: The association between Alzheimer's disease pathology and anxiety and apathy is partly due to impairment in cognitive functioning. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/66568f67-b1bb-4dd6-ae58-406df9c02fc3Test |
| DOI: | 10.1016/j.jagp.2020.01.012 |
| الإتاحة: | https://doi.org/10.1016/j.jagp.2020.01.012Test https://research.vumc.nl/en/publications/66568f67-b1bb-4dd6-ae58-406df9c02fc3Test http://www.scopus.com/inward/record.url?scp=85079853175&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.404A6CC1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jagp.2020.01.012 |
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