دورية أكاديمية
Uphill battle:Innovation of thiopurine therapy in global inflammatory bowel disease care
| العنوان: | Uphill battle:Innovation of thiopurine therapy in global inflammatory bowel disease care |
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| المؤلفون: | Bayoumy, Ahmed B., Mulder, Chris J. J., Ansari, Azhar R., Barclay, Murray L., Florin, Tim, Kiszka-Kanowitz, Marianne, Derijks, Luc, Sharma, Vishal, de Boer, Nanne K. H. |
| المصدر: | Bayoumy , A B , Mulder , C J J , Ansari , A R , Barclay , M L , Florin , T , Kiszka-Kanowitz , M , Derijks , L , Sharma , V & de Boer , N K H 2024 , ' Uphill battle : Innovation of thiopurine therapy in global inflammatory bowel disease care ' , Indian Journal of Gastroenterology , vol. 43 , no. 1 , pp. 36-47 . https://doi.org/10.1007/s12664-024-01529-xTest |
| سنة النشر: | 2024 |
| الوصف: | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses two major conditions: Crohn’s disease (CD) and ulcerative colitis (UC). Historically, IBD has been primarily reported in western countries, but over the past decades, its prevalence is rapidly increasing, especially in lower and middle-income countries (LMICs) such as India and China and also in Sub-Saharan Africa. The prevalence of IBD in LMICs has been the subject of growing concern due to the impact of access to public healthcare and the burden it places on healthcare resources. The classical thiopurines face significant challenges due to cessation of therapy in approximately half of patients within one year due to side effects or ineffectiveness. In this article, we highlight innovating thiopurine treatment for IBD patients in downregulating side effects and improving efficacy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/afc79707-5673-4e9e-95aa-b5b6ac91296fTest |
| DOI: | 10.1007/s12664-024-01529-x |
| الإتاحة: | https://doi.org/10.1007/s12664-024-01529-xTest https://research.vumc.nl/en/publications/afc79707-5673-4e9e-95aa-b5b6ac91296fTest http://www.scopus.com/inward/record.url?scp=85185965358&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3FD48EC2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12664-024-01529-x |
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