دورية أكاديمية
Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases
العنوان: | Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases |
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المؤلفون: | Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone, Sara Soldi, Marina Elli, Piera Valenti, Luigi Rosa |
المصدر: | Gels, Vol 9, Iss 8, p 607 (2023) |
بيانات النشر: | MDPI AG |
سنة النشر: | 2023 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | Tau-Marin, mucoadhesive gel, oral formulation, probiotics, periodontitis, periodontal diseases, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65 |
الوصف: | An innovative and stable probiotic-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated with periodontal diseases. Tau-Marin gel, prepared with anhydrous ingredients to prevent the replication of bacteria and ensure good stability over time, was tested against some pathogenic bacteria, belonging to the so-called “red complex”, recognized as the most important pathogens in plaque specimens, adherent to the epithelial lining of periodontal pockets. This lipogel was tested in vitro, in a physiological solution (PS) and in a simulated saliva (SS), for up to 8 h, to monitor its ability to release probiotics over time. Probiotics were enumerated through two different techniques, Lacto-Counter Assay (LCA) and Colony Forming Unit (CFU). A detailed physico-chemical profile of AL0020 and its in vitro efficacy in protecting activity against pathogenic bacteria as well as soothing or irritative effect on gingival epithelium were reported. Moreover, a clinical-dermatological trial on 20 volunteers using the product once a day for 30 days was also performed, where the efficacy of the gel in the control of gum disorders was observed. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 2310-2861 |
العلاقة: | https://www.mdpi.com/2310-2861/9/8/607Test; https://doaj.org/toc/2310-2861Test; https://doaj.org/article/4d3f2839fdcf4970ad85a9ccee41689eTest |
DOI: | 10.3390/gels9080607 |
الإتاحة: | https://doi.org/10.3390/gels9080607Test https://doaj.org/article/4d3f2839fdcf4970ad85a9ccee41689eTest |
رقم الانضمام: | edsbas.3F7E6C77 |
قاعدة البيانات: | BASE |
تدمد: | 23102861 |
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DOI: | 10.3390/gels9080607 |