دورية أكاديمية
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner.
| العنوان: | Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner. |
|---|---|
| المؤلفون: | Papotto, Pedro H, Yilmaz, Bahtiyar, Pimenta, Gonçalo, Mensurado, Sofia, Cunha, Carolina, Fiala, Gina J, Gomes da Costa, Daniel, Gonçalves-Sousa, Natacha, Chan, Brian H K, Blankenhaus, Birte, Domingues, Rita G, Carvalho, Tânia, Hepworth, Matthew R, Macpherson, Andrew J, Allen, Judith E, Silva-Santos, Bruno |
| المصدر: | Papotto, Pedro H; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina J; Gomes da Costa, Daniel; Gonçalves-Sousa, Natacha; Chan, Brian H K; Blankenhaus, Birte; Domingues, Rita G; Carvalho, Tânia; Hepworth, Matthew R; Macpherson, Andrew J; Allen, Judith E; Silva-Santos, Bruno (2023). Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner. Cell reports, 42(2), p. 112074. Cell Press 10.1016/j.celrep.2023.112074 |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ-/-) dams display an increase in first-breath-induced inflammation, with a pulmonary milieu selectively enriched in type 2 cytokines and type 2-polarized immune cells, when compared with the progeny of γδ T cell-sufficient dams. Upon helminth infection, mice born from TCRδ-/- dams sustain an increased type 2 inflammatory response. This is independent of the genotype of the pups. Instead, the offspring of TCRδ-/- dams harbors a distinct intestinal microbiota, acquired during birth and fostering, and decreased levels of intestinal short-chain fatty acids (SCFAs), such as pentanoate and hexanoate. Importantly, exogenous SCFA supplementation inhibits type 2 innate lymphoid cell function and suppresses first-breath- and infection-induced inflammation. Taken together, our findings unravel a maternal γδ T cell-microbiota-SCFA axis regulating neonatal lung immunity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://boris.unibe.ch/178823Test/ |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2023.112074Test https://boris.unibe.ch/178823/1/1-s2.0-S2211124723000852-main.pdfTest https://boris.unibe.ch/178823Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3F6E04C3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |