دورية أكاديمية
Antipsychotic medications and sleep problems in patients with schizophrenia
| العنوان: | Antipsychotic medications and sleep problems in patients with schizophrenia |
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| المؤلفون: | Cederlöf, Erik, Holm, Minna, Taipale, Heidi, Tiihonen, Jari, Tanskanen, Antti, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kampman, Olli, Wegelius, Asko, Isometsä, Erkki, Kieseppä, Tuula, Palotie, Aarno, Suvisaari, Jaana, Paunio, Tiina, Kyttälä, Aija, Kämpe, Anders, Tuulio-Henriksson, Annamari, Ahola-Olli, Ari, Toivola, Auli, Neale, Benjamin, Shen, Huei-yi, Västrik, Imre, Lönnqvist, Jouko, Veijola, Juha, Niemi-Pynttäri, Jussi, Häkkinen, Katja, Suokas, Kimmo, Daly, Mark, Ristiluoma, Noora, Pietiläinen, Olli, Kajanne, Risto, Hyman, Steven E., Singh, Tarjinder, Männynsalo, Teemu, Jukuri, Tuomas, Haaki, Willehard |
| بيانات النشر: | UmeÃ¥ universitet, Psykiatri Finnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland Finnish Institute for Health and Welfare, Finland Karolinska Institutet, Sweden; Niuvanniemi Hospital, University of Eastern Finland, Finland Karolinska Institutet, Sweden Niuvanniemi Hospital, University of Eastern Finland, Finland Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland University of Tampere, Faculty of Medicine and Health Technology, Finland; University of Turku, Faculty of Medicine, Finland; The Pirkanmaa Wellbeing Services County, Department of Psychiatry, Tampere, Finland; The Wellbeing Services County of Ostrobothnia, Department of Psychiatry, Finland Finnish Ministry of Social Affairs and Health, Finland Institute for Molecular Medicine, Finland Institute for Molecular Medicine Finland, Finland Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Department of Psychiatry, University Hospital of Oulu, Finland Tampere University Hospital, Finland Tampere University Hospital, Finland; Department of Psychiatry, Pirkanmaa Hospital District, Finland Finnish Institute for Health and Welfare, Finland; Institute for Molecular Medicine Finland, Finland; Massachusetts General Hospital Massachusetts General Hospital, United States Neuroscience Center, HiLIFE, University of Helsinki, Finland Department of Psychiatry, University Hospital of Oulu, Finland Turku University Hospital, Turku, Finland |
| سنة النشر: | 2024 |
| المجموعة: | Umeå University: Publications (DiVA) |
| مصطلحات موضوعية: | Antipsychotics, Hypersomnia, Insomnia, Schizophrenia, Sleep, Psychiatry, Psykiatri |
| الوصف: | Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear. Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h). Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83–2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98–4.44, p < .001). Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Schizophrenia Research, 0920-9964, 2024, 267, s. 230-238; orcid:0000-0001-6891-2266; http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223506Test; Scopus 2-s2.0-85189811509 |
| DOI: | 10.1016/j.schres.2024.03.015 |
| الإتاحة: | https://doi.org/10.1016/j.schres.2024.03.015Test http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223506Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3F68CDE5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.schres.2024.03.015 |
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