دورية أكاديمية
The inferior whorl for detecting diabetic peripheral neuropathy using corneal confocal microscopy
| العنوان: | The inferior whorl for detecting diabetic peripheral neuropathy using corneal confocal microscopy |
|---|---|
| المؤلفون: | Petropoulos, Ioannis, Ferdousi, Maryam, Marshall, Andrew, Alam, Uazman, Ponirakis, Georgios, Azmi, Shazli, Fadavi, Hassan, Efron, Nathan, Tavakoli, Mitra, Malik, Rayaz |
| المصدر: | Investigative Ophthalmology and Visual Science |
| بيانات النشر: | Association for Research in Vision and Ophthalmology Inc. |
| سنة النشر: | 2015 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| الوصف: | PURPOSE: In vivo corneal confocal microscopy (CCM) is increasingly used as a surrogate endpoint in studies of diabetic polyneuropathy (DPN). However, it is not clear whether imaging the central cornea provides optimal diagnostic utility for DPN. Therefore, we compared nerve morphology in the central cornea and the inferior whorl, a more distal and densely innervated area located inferior and nasal to the central cornea. METHODS: A total of 53 subjects with type 1/type 2 diabetes and 15 age-matched control subjects underwent detailed assessment of neuropathic symptoms (NPS), deficits (neuropathy disability score [NDS]), quantitative sensory testing (vibration perception threshold [VPT], cold and warm threshold [CT/WT], and cold- and heat-induced pain [CIP/HIP]), and electrophysiology (sural and peroneal nerve conduction velocity [SSNCV/PMNCV], and sural and peroneal nerve amplitude [SSNA/PMNA]) to diagnose patients with (DPN+) and without (DPN-) neuropathy. Corneal nerve fiber density (CNFD) and length (CNFL) in the central cornea, and inferior whorl length (IWL) were quantified. RESULTS: Comparing control subjects to DPN- and DPN+ patients, there was a significant increase in NDS (0 vs. 2.6 ± 2.3 vs. 3.3 ± 2.7, P < 0.01), VPT (V; 5.4 ± 3.0 vs. 10.6 ± 10.3 vs. 17.7 ± 11.8, P < 0.01), WT (°C; 37.7 ± 3.5 vs. 39.1 ± 5.1 vs. 41.7 ± 4.7, P < 0.05), and a significant decrease in SSNCV (m/s; 50.2 ± 5.4 vs. 48.4 ± 5.0 vs. 39.5 ± 10.6, P < 0.05), CNFD (fibers/mm2; 37.8 ± 4.9 vs. 29.7 ± 7.7 vs. 27.1 ± 9.9, P < 0.01), CNFL (mm/mm2; 27.5 ± 3.6 vs. 24.4 ± 7.8 vs. 20.7 ± 7.1, P < 0.01), and IWL (mm/mm2; 35.1 ± 6.5 vs. 26.2 ± 10.5 vs. 23.6 ± 11.4, P < 0.05). For the diagnosis of DPN, CNFD, CNFL, and IWL achieved an area under the curve (AUC) of 0.75, 0.74, and 0.70, respectively, and a combination of IWL-CNFD achieved an AUC of 0.76. CONCLUSIONS: The parameters of CNFD, CNFL, and IWL have a comparable ability to diagnose patients with DPN. However, IWL detects an abnormality even in patients without DPN. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/92222/1/92222.pdfTest; Petropoulos, Ioannis, Ferdousi, Maryam, Marshall, Andrew, Alam, Uazman, Ponirakis, Georgios, Azmi, Shazli, Fadavi, Hassan, Efron, Nathan, Tavakoli, Mitra, & Malik, Rayaz (2015) The inferior whorl for detecting diabetic peripheral neuropathy using corneal confocal microscopy. Investigative Ophthalmology and Visual Science, 56(4), pp. 2498-2504.; https://eprints.qut.edu.au/92222Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.1167/iovs.14-15919Test https://eprints.qut.edu.au/92222Test/ |
| حقوق: | free_to_read ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.3F208571 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |