كتاب
The Extended Clearance Model
العنوان: | The Extended Clearance Model |
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المؤلفون: | Poller, Birk, Huth, Felix, Kastrinou‐Lampou, Vlasia, Kullak‐Ublick, Gerd A, Arand, Michael, Camenisch, Gian |
المساهمون: | Li, Albert P, Li, A P ( Albert P ) |
المصدر: | Poller, Birk; Huth, Felix; Kastrinou‐Lampou, Vlasia; Kullak‐Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2021). The Extended Clearance Model. In: Li, Albert P. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. Hoboken, New Jersey: John Wiley & Sons, 455-479. |
بيانات النشر: | John Wiley & Sons |
سنة النشر: | 2021 |
المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
مصطلحات موضوعية: | Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health |
الوصف: | Cell stress perturbations in the liver are frequently the result of inhibitory insults on hepatic enzyme- and/or transporter-mediated processes involved in the disposition of bile acids and/or bilirubin. Hence, in recent years, more or less complex drug–drug interaction (DDI) prediction techniques (so-called R-value models) were derived to anticipate the overall drug-induced liver injury (DILI) risk of new chemical entities. This article aims to provide an integrated overview of our latest in-house efforts to forecast quantitatively, cell stress-based DILI predominantly by integrating principles of the extended clearance model (ECM). |
نوع الوثيقة: | book part |
اللغة: | English |
ردمك: | 978-1-119-17084-6 1-119-17084-2 |
العلاقة: | https://www.zora.uzh.ch/223030Test; urn:isbn:978-1-119-17084-6 |
DOI: | 10.1002/9781119171003.ch15 |
الإتاحة: | https://doi.org/10.1002/9781119171003.ch15Test https://www.zora.uzh.ch/id/eprint/223030Test/ https://www.zora.uzh.ch/223030Test |
حقوق: | info:eu-repo/semantics/closedAccess |
رقم الانضمام: | edsbas.3F1569F7 |
قاعدة البيانات: | BASE |
ردمك: | 9781119170846 1119170842 |
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DOI: | 10.1002/9781119171003.ch15 |