دورية أكاديمية
Divergent SATB1 expression across human life span and tissue compartments
| العنوان: | Divergent SATB1 expression across human life span and tissue compartments |
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| المؤلفون: | Nüssing, Simone, Koay, Hui-Fern, Sant, Sneha, Loudovaris, Thomas, Mannering, Stuart I., Lappas, Martha, d'Udekem, Yves, Konstantinov, Igor E., Berzins, Stuart P., Rimmelzwaan, Guus F., Turner, Stephen J., Clemens, E. Bridie, Godfrey, Dale I., Nguyen, Thi Ho, Kedzierska, Katherine |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | article, Verzeichnis wissenschaftlicher Veröffentlichungen, ddc:630, Hochschulbibliographie allgemein, CD8-Positive T-Lymphocytes, Humans, Matrix Attachment Region Binding Proteins, Organ Specificity, Gene Expression Regulation, Aging, Adult, Aged, Middle Aged, Child, Preschool, Infant, Newborn, Female, Male, Programmed Cell Death 1 Receptor, Thymocytes, PD-1, SATB1, Human Cd8+ T Cells |
| الوقت: | 2019 |
| الوصف: | Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription in mice and humans. The role of SATB1 is pivotal for T-cell development, with SATB1-knockout mice being neonatally lethal, although the exact mechanism is unknown. Moreover, SATB1 is dysregulated in T-cell lymphoma and proposed to suppress transcription of the Pdcd1 gene, encoding the immune checkpoint programmed cell death protein 1 (PD-1). Thus, SATB1 expression in T-cell subsets across different tissue compartments in humans is of potential importance for targeting PD-1. Here, we comprehensively analyzed SATB1 expression across different human tissues and immune compartments by flow cytometry and correlated this with PD-1 expression. We investigated SATB1 protein levels in pediatric and adult donors and assessed expression dynamics of this chromatin organizer across different immune cell subsets in human organs, as well as in antigen-specific T cells directed against acute and chronic viral infections. Our data demonstrate that SATB1 expression in humans is the highest in T-cell progenitors in the thymus, and then becomes downregulated in mature T cells in the periphery. Importantly, SATB1 expression in peripheral mature T cells is not static and follows fine-tuned expression dynamics, which appear to be tissue- and antigen-dependent. Furthermore, SATB1 expression negatively correlates with PD-1 expression in virus-specific CD8+ T cells. Our study has implications for understanding the role of SATB1 in human health and disease and suggests an approach for modulating PD-1 in T cells, highly relevant to human malignancies or chronic viral infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Immunology and cell biology -- Immunol. Cell Biol. -- Immunology & cell biology -- 2011707-3 -- 1440-1711 -- 0818-9641 -- https://onlinelibrary.wiley.com/journal/14401711Test -- http://rzblx1.uni-regensburg.de/ezeit/searchres.phtml?bibid=TIHO&colors=7&lang=de&jq_type1=QS&jq_term1=Immunology+and+cell+biologyTest; https://doi.org/10.1111/imcb.12233Test; https://elib.tiho-hannover.de/receive/tiho_mods_00001841Test; https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000475/imcb.12233.pdfTest; https://europepmc.org/articles/PMC6618325Test |
| DOI: | 10.1111/imcb.12233 |
| الإتاحة: | https://doi.org/10.1111/imcb.12233Test https://elib.tiho-hannover.de/receive/tiho_mods_00001841Test https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000475/imcb.12233.pdfTest https://europepmc.org/articles/PMC6618325Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3E8017E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/imcb.12233 |
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