دورية أكاديمية
Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials
| العنوان: | Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials |
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| المؤلفون: | Monami, M., Ahrén, Bo, Dicembrini, I., Mannucci, E. |
| المصدر: | Diabetes, Obesity and Metabolism; 15(2), pp 112-120 (2013) ; ISSN: 1462-8902 |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2013 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Endocrinology and Diabetes, cardiac complications, macrovascular disease, oral pharmacological, agents |
| الوصف: | Aims Preliminary data from randomized trials with metabolic outcomes have shown that treatment with dipeptidyl peptidase-4 inhibitors (DPP4i) could be associated with a reduced incidence of major cardiovascular events (MACE). The present meta-analysis is aimed at verifying this protective effect, collecting all available data from randomized trials. Methods A comprehensive search for published and unpublished trials with a duration =24 weeks comparing DPP4i with placebo or other drugs was performed, retrieving all MACE reported as serious adverse events together with death from any cause. MantelHaenzel odds ratio (MHOR) was calculated with random effect models for MACE, myocardial infarction, stroke and mortality. When available, effects on glycated haemoglobin, lipid profile and blood pressure were also assessed and used for the estimation of the modification of risk for myocardial infarction using the UKPDS risk engine. Results A total of 70 trials, enrolling 41?959 patients with a mean follow-up of 44.1 weeks, was collected and included in the analysis. The MHOR (95% Confidence Interval) was 0.71[0.59;0.86], 0.64[0.44;0.94], 0.77[0.48;1.24] and 0.60[0.41;0.88] for MACE, myocardial infarction, stroke and mortality, respectively. Conclusions Treatment with DPP4i reduces the risk of cardiovascular events (particularly myocardial infarction) and all-cause mortality in patients with type 2 diabetes. The reduction in the incidence of myocardial infarction is greater than what predicted on the basis of conventional risk factors, suggesting a role for other mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/3481412Test; http://dx.doi.org/10.1111/dom.12000Test; wos:000312997300002; scopus:84871936025; pmid:22925682 |
| DOI: | 10.1111/dom.12000 |
| الإتاحة: | https://doi.org/10.1111/dom.12000Test https://lup.lub.lu.se/record/3481412Test |
| رقم الانضمام: | edsbas.3E2E3C1C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/dom.12000 |
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