دورية أكاديمية
Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
| العنوان: | Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging |
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| المؤلفون: | Yu, Mengdi, Zhang, Hongxia, Wang, Brian, Zhang, Yinuo, Zheng, Xiaoying, Shao, Bei, Zhuge, Qichuan, Jin, Kunlin |
| المصدر: | Cells |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | UNTHSC Scholarly Repository (University. of North Texas Health Science Center) |
| مصطلحات موضوعية: | metabolism, ampk, sirt1, aging, health span, intervention, mTOR, senescence, signaling, AMP-Activated Protein Kinases / metabolism, Age Factors, Animals, Biomarkers / metabolism, Cognition / drug effects, Cognitive Aging, Enzyme Activation, Enzyme Activators / therapeutic use, Functional Status, Healthy Aging / drug effects, Healthy Aging / metabolism, Healthy Aging / psychology, Humans, Mental Health, Molecular Targeted Therapy, Protein Kinase Inhibitors / therapeutic use, Signal Transduction / drug effects, Sirtuin 1 / metabolism, TOR Serine-Threonine Kinases / antagonists & inhibitors, TOR Serine-Threonine Kinases / metabolism |
| الوصف: | Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease. ; This research received no external funding. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| تدمد: | 2073-4409 |
| العلاقة: | https://doi.org/10.3390/cells10030660Test; Yu, M., Zhang, H., Wang, B., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021). Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging. Cells, 10(3), 660. https://doi.org/10.3390/cells10030660Test; https://hdl.handle.net/20.500.12503/31700Test; 10 |
| الإتاحة: | https://doi.org/20.500.12503/31700Test https://doi.org/10.3390/cells10030660Test https://hdl.handle.net/20.500.12503/31700Test |
| حقوق: | Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ ; © 2021 by the authors. |
| رقم الانضمام: | edsbas.3E1EB3B3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734409 |
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