دورية أكاديمية
Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial
| العنوان: | Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial |
|---|---|
| المؤلفون: | Kamer, O., Rinott, E., Tsaban, G., Kaplan, A., Yaskolka Meir, A., Zelicha, H., Knights, D., Tuohy, K., Fava, F., Uwe Scholz, M., Ziv, O., Rubin, E., Blüher, M., Stumvoll, M., Ceglarek, U., Clément, K., Koren, O., Hu, F.B., Stampfer, M.J., Wang, D.D., Youngster, I., Shai, I. |
| بيانات النشر: | Informa UK Limited |
| سنة النشر: | 2023 |
| المجموعة: | White Rose Research Online (Universities of Leeds, Sheffield & York) |
| الوصف: | We previously reported that autologous-fecal-microbiota-transplantation (aFMT), following 6 m of lifestyle intervention, attenuated subsequent weight regain and insulin rebound for participants consuming a high-polyphenol green-Mediterranean diet. Here, we explored whether specific changes in the core (abundant) vs. non-core (low-abundance) gut microbiome taxa fractions during the weight-loss phase (0–6 m) were differentially associated with weight maintenance following aFMT. Eighty-two abdominally obese/dyslipidemic participants (age = 52 years; 6 m weightloss = −8.3 kg) who provided fecal samples (0 m, 6 m) were included. Frozen 6 m’s fecal samples were processed into 1 g, opaque and odorless aFMT capsules. Participants were randomly assigned to receive 100 capsules containing their own fecal microbiota or placebo over 8 m-14 m in ten administrations (adherence rate > 90%). Gut microbiome composition was evaluated using shotgun metagenomic sequencing. Non-core taxa were defined as ≤ 66% prevalence across participants. Overall, 450 species were analyzed. At baseline, 13.3% were classified as core, and Firmicutes presented the highest core proportion by phylum. During 6 m weight-loss phase, abundance of non-core species changed more than core species (P <.0001). Subject-specific changes in core and non-core taxa fractions were strongly correlated (Jaccard Index; r = 0.54; P <.001). Following aFMT treatment, only participants with a low 6 m change in core taxa, and a high change in non-core taxa, avoided 8–14 m weight regain (aFMT = −0.58 ± 2.4 kg, corresponding placebo group = 3.18 ± 3.5 kg; P =.02). In a linear regression model, low core/high non-core 6 m change was the only combination that was significantly associated with attenuated 8–14 m weight regain (P =.038; P =.002 for taxa patterns/treatment intervention interaction). High change in non-core, low-abundance taxa during weight-loss might mediate aFMT treatment success for weight loss maintenance. ClinicalTrials.gov: NCT03020186. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://eprints.whiterose.ac.uk/204814/1/Successful%20weight%20regain%20attenuation%20by%20autologous%20fecal%20microbiota%20transplantation%20is%20associated%20with%20non-core%20gut%20microbiota%20changes%20during%20weight%20l.pdfTest; Kamer, O. orcid.org/0009-0003-2486-3898 , Rinott, E., Tsaban, G. et al. (19 more authors) (2023) Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial. Gut Microbes, 15 (2). 2264457. ISSN 1949-0976 |
| DOI: | 10.1080/19490976.2023.2264457 |
| الإتاحة: | https://doi.org/10.1080/19490976.2023.2264457Test https://eprints.whiterose.ac.uk/204814Test/ https://eprints.whiterose.ac.uk/204814/1/Successful%20weight%20regain%20attenuation%20by%20autologous%20fecal%20microbiota%20transplantation%20is%20associated%20with%20non-core%20gut%20microbiota%20changes%20during%20weight%20l.pdfTest |
| حقوق: | cc_by_nc_4 |
| رقم الانضمام: | edsbas.3DF1D3F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/19490976.2023.2264457 |
|---|