دورية أكاديمية
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
| العنوان: | Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure |
|---|---|
| المؤلفون: | Koenig, Andrew L., Shchukina, Irina, Amrute, Junedh, Andhey, Prabhakar S., Zaitsev, Konstantin, Lai, Lulu, Bajpai, Geetika, Bredemeyer, Andrea, Smith, Gabriella, Jones, Cameran, Terrebonne, Emily, Rentschler, Stacey L., Artyomov, Maxim N., Lavine, Kory J. |
| المساهمون: | American Heart Association, U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute, Burroughs Wellcome Fund, Fondation Leducq |
| المصدر: | Nature Cardiovascular Research ; volume 1, issue 3, page 263-280 ; ISSN 2731-0590 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression. Through integrated analysis of single-cell and single-nucleus RNA-sequencing data generated from 27 healthy donors and 18 individuals with dilated cardiomyopathy, here we define the cell composition of the healthy and failing human heart. We identify cell-specific transcriptional signatures associated with age and heart failure and reveal the emergence of disease-associated cell states. Notably, cardiomyocytes converge toward common disease-associated cell states, whereas fibroblasts and myeloid cells undergo dramatic diversification. Endothelial cells and pericytes display global transcriptional shifts without changes in cell complexity. Collectively, our findings provide a comprehensive analysis of the cellular and transcriptomic landscape of human heart failure, identify cell type-specific transcriptional programs and disease-associated cell states and establish a valuable resource for the investigation of human heart failure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s44161-022-00028-6 |
| الإتاحة: | https://doi.org/10.1038/s44161-022-00028-6Test https://www.nature.com/articles/s44161-022-00028-6.pdfTest https://www.nature.com/articles/s44161-022-00028-6Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.3DB5F6D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s44161-022-00028-6 |
|---|