دورية أكاديمية
Framework for the quality assurance of ’omics technologies considering GLP requirements
| العنوان: | Framework for the quality assurance of ’omics technologies considering GLP requirements |
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| المؤلفون: | Kauffmann, H.-M., Kamp, H., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, Jörg, Perdichizzi, S., Poole, A., Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. |
| المصدر: | ISSN: 0273-2300. |
| بيانات النشر: | Elsevier Regulatory Toxicology and Pharmacology 91 (Suppl. 1);; S27 - S35 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Good laboratory practice (GLP), Standard operating procedure, Independent quality assurance, Documentation, Data storage, Reproducibility, Raw data definition, Software validation, Quality assurance inspection |
| الوصف: | ‘Omics technologies are gaining importance to support regulatory toxicity studies. Prerequisites for performing ‘omics studies considering GLP principles were discussed at the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Workshop Applying ‘omics technologies in Chemical Risk Assessment. A GLP environment comprises a standard operating procedure system, proper pre-planning and documentation, and inspections of independent quality assurance staff. To prevent uncontrolled data changes, the raw data obtained in the respective ‘omics data recording systems have to be specifically defined. Further requirements include transparent and reproducible data processing steps, and safe data storage and archiving procedures. The software for data recording and processing should be validated, and data changes should be traceable or disabled. GLP-compliant quality assurance of ‘omics technologies appears feasible for many GLP requirements. However, challenges include (i) defining, storing, and archiving the raw data; (ii) transparent descriptions of data processing steps; (iii) software validation; and (iv) ensuring complete reproducibility of final results with respect to raw data. Nevertheless, ‘omics studies can be supported by quality measures (e.g., GLP principles) to ensure quality control, reproducibility and traceability of experiments. This enables regulators to use ‘omics data in a fit-for-purpose context, which enhances their applicability for risk assessment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19425Test; https://dx.doi.org/10.1016/j.yrtph.2017.10.007Test |
| DOI: | 10.1016/j.yrtph.2017.10.007 |
| الإتاحة: | https://doi.org/10.1016/j.yrtph.2017.10.007Test https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19425Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3D0860E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.yrtph.2017.10.007 |
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