التفاصيل البيبلوغرافية
| العنوان: |
Application of CytoMatrix for the diagnosis of melanoma metastases on FNA cytology samples: Performance of a novel cell block method |
| المؤلفون: |
Montella, Marco, Cozzolino, Immacolata, Zito Marino, Federica, Clery, Eduardo, Carraturo, Emma, Brancaccio, Gabriella, Argenziano, Giuseppe, Troiani, Teresa, Savarese, Giovanni, Berretta, Massimiliano, Franco, Renato, Ronchi, Andrea |
| المصدر: |
Cancer Cytopathology ; volume 131, issue 8, page 516-525 ; ISSN 1934-662X 1934-6638 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background The management of cytological samples can significantly impact diagnostic interpretation. Cell blocks (CB) are a popular method due to their ability to provide additional morphological information and be used for immunocytochemistry and molecular tests. Recently, a new CB technique called the synthetic matrix CytoMatrix (CM) has been introduced, which can gather and hold cytological material within its three‐dimensional structure. Methods In this study, 40 cytological samples from patients with melanoma metastases were analyzed to evaluate the diagnostic performance of CM compared to another CB method used in the laboratory. The researchers assessed the morphological adequacy of the two techniques, as well as their performance in immunocytochemical analysis and molecular. Results This study showed that CM was quicker and equally effective compared to the other method, with the laboratory technician having less of an impact on the CM approach across all passages. Additionally, all CMs were adequate, whereas the other method was adequate in 90% of cases. Immunocytochemistry confirmed the diagnosis of melanoma metastases in all cases, and all 40 CMs and 36 of the other method were adequate for fluorescence in situ hybridization analysis. Conclusion CM is a low‐time‐consuming technology that is unaffected by technicians during all setup phases, making it simpler to standardize the procedure. Moreover, a low loss of diagnostic cells ensures greater benefits for morphological analysis, immunocytochemistry, and molecular testing. Overall, the study highlights the potential of CM as a valuable technique for managing cytological samples. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/cncy.22707 |
| الإتاحة: |
https://doi.org/10.1002/cncy.22707Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.3CECD709 |
| قاعدة البيانات: |
BASE |
