دورية أكاديمية
Hyaluronate nanoparticles included in polymer films for the prolonged release of vitamin E for the management of skin wounds
| العنوان: | Hyaluronate nanoparticles included in polymer films for the prolonged release of vitamin E for the management of skin wounds |
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| المؤلفون: | G. G. Pereira, C. B. Detoni, A. G. Balducci, V. Rondelli, P. Colombo, S. S. Guterres, F. Sonvico |
| المساهمون: | G.G. Pereira, C.B. Detoni, A.G. Balducci, V. Rondelli, P. Colombo, S.S. Guterre, F. Sonvico |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | wound healing, vitamin e, hyaluronate nanoparticle, polymer film, local delivery, burns, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) |
| الوصف: | Lecithin and hyaluronic acid were used for the preparation of polysaccharide decorated nanoparticles loaded with vitamin E using the cationic lipid dioctadecyldimethylammonium bromide (DODMA). Nanoparticles showed mean particle size in the range 130–350 nm and narrow size distribution. Vitamin E encapsulation efficiency was higher than 99%. These nanoparticles were incorporated in polymeric films containing Aloe vera extract, hyaluronic acid, sodium alginate, polyethyleneoxide (PEO) and polyvinylalcohol (PVA) as an innovative treatment in skin wounds. Films were thin, flexible, resistant and suitable for application on burn wounds. Additionally, in vitro occlusion study highlighted the dependence of the occlusive effect on the presence of nanoparticles. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of skin wounds, such as burns. The controlled release of the vitamin along with a reduction in water loss through damaged skin provided by the nanoparticle-loaded polymer film are considered important features for an improvement in wound healing and skin regeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26769495; info:eu-repo/semantics/altIdentifier/wos/WOS:000370187300022; volume:83; firstpage:203; lastpage:211; numberofpages:9; journal:EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES; http://hdl.handle.net/2434/502773Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84954349550 |
| DOI: | 10.1016/j.ejps.2016.01.002 |
| الإتاحة: | https://doi.org/10.1016/j.ejps.2016.01.002Test http://hdl.handle.net/2434/502773Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3C712DBC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejps.2016.01.002 |
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