دورية أكاديمية
Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors.
| العنوان: | Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors. |
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| المؤلفون: | RUBIN, BEATRICE, REDAELLI, MARCO, MUCIGNAT, CARLA, BAROLLO, SUSI, BERTAZZA, LORIS, MIAN, CATERINA, BETTERLE, CORRADO, IACOBONE, MAURIZIO, FASSINA, AMBROGIO, BOSCARO, MARCO, PEZZANI, RAFFAELE, MANTERO, FRANCO, MONTICELLI, HALENYA |
| المساهمون: | Rubin, Beatrice, Monticelli, Halenya, Redaelli, Marco, Mucignat, Carla, Barollo, Susi, Bertazza, Lori, Mian, Caterina, Betterle, Corrado, Iacobone, Maurizio, Fassina, Ambrogio, Boscaro, Marco, Pezzani, Raffaele, Mantero, Franco |
| بيانات النشر: | TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA |
| سنة النشر: | 2015 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | BRAF, MAPK signaling pathway, RAS, Adrenocortical tumor, Adrenocortical carcinomas |
| الوصف: | Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no concrete data confirming alteration rate. The objective of this study was to evaluate genetic alterations in key components of MAPK pathway. We found one BRAF mutation (p.V600E) and four HRAS silent mutations. No alteration was found in NRAS, KRAS, EGFR genes. The patient carrying BRAF mutation was further characterized by investigating his biomolecular and clinico-pathological findings. Therefore, even if MAPK signaling is activated in ACT, our results suggest that genetic alterations do not seem to represent a frequent mechanism of ACT tumorigenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26536286; info:eu-repo/semantics/altIdentifier/wos/WOS:000366319000009; volume:33; issue:10; firstpage:526; lastpage:531; numberofpages:6; journal:CANCER INVESTIGATION; http://hdl.handle.net/11577/3178213Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84949725383 |
| DOI: | 10.3109/07357907.2015.1080832 |
| الإتاحة: | https://doi.org/10.3109/07357907.2015.1080832Test http://hdl.handle.net/11577/3178213Test |
| رقم الانضمام: | edsbas.3C4D2A70 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3109/07357907.2015.1080832 |
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