صورة
Image1_Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats.pdf
| العنوان: | Image1_Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats.pdf |
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| المؤلفون: | Oluwafemi Adeleke Ojo, Abosede Itunuoluwa Oni, Susan Grant, Jennifer Amanze, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Rotdelmwa Filibus Maimako, Ikponmwosa Owen Evbuomwan, Matthew Iyobhebhe, Charles Obiora Nwonuma, Omorefosa Osemwegie, Anthonia Oluyemi Agboola, Christopher Akintayo, Nnaemeka Tobechukwu Asogwa, Nada H. Aljarba, Saad Alkahtani, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha, Oluyomi Stephen Adeyemi |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers: Figshare |
| مصطلحات موضوعية: | Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, diabetes, inflammation, apoptosis, PI3K/akt signalling pathway, aqueous extract of Cenchrus purpureus |
| الوصف: | Ethnopharmacological Relevance: The management of diabetes over the years has involved the use of herbal plants, which are now attracting interest. We assessed the antidiabetic properties of aqueous extract of C. purpureus shoots (AECPS) and the mechanism of action on pancreatic ß-cell dysfunction. Methods: This study was conducted using Thirty-six 36) male Wistar rats. The animals were divided into six equal groups (n = 6) and treatment was performed over 14 days. To induce diabetes in the rats, a single dose of 65 mg/kg body weight of alloxan was administered intraperitoneal along with 5% glucose. HPLC analysis was carried out to identified potential compounds in the extract. In vitro tests α-amylase, and α-glucosidase were analyzed. Body weight and fasting blood glucose (FBG) were measured. Biochemical parameters, such as serum insulin, liver glycogen, hexokinase, glucose-6-phosphate (G6P), fructose-1,6-bisphosphatase (F-1,6-BP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-ĸB), were analyzed. Additionally, mRNA expressions of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), B-cell lymphoma 2 (Bcl-2), and proliferating cell nuclear antigen (PCNA) were each evaluated. Results: This in vitro study showed inhibitory potency of Cenchrus purpureus extract (AECPS) as compared with the positive controls. AECPS showed a gradual decrease in alloxan-induced increases in FBG, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-c), G6P, F-1,6-BP, malondialdehyde (MDA), IL-6, TNF-α, and NF-ĸB and increased alloxan-induced decreases in liver glycogen, hexokinase, and high density lipoprotein (HDL-c). The diabetic control group exhibited pancreatic dysfunction as evidenced by the reduction in serum insulin, homeostasis model assessment of ß-cell function (HOMA-β), expressions of PI3K/AKT, Bcl-2, and PCNA combined with an elevation in homeostatic model assessment of insulin resistance (HOMA-IR). High performance liquid chromatography (HPLC) revealed ... |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Image1_Antidiabetic_Activity_of_Elephant_Grass_Cenchrus_Purpureus_Schumach_Morrone_via_Activation_of_PI3K_AkT_Signaling_Pathway_Oxidative_Stress_Inhibition_and_Apoptosis_in_Wistar_Rats_pdf/19289231Test |
| DOI: | 10.3389/fphar.2022.845196.s001 |
| الإتاحة: | https://doi.org/10.3389/fphar.2022.845196.s001Test https://figshare.com/articles/figure/Image1_Antidiabetic_Activity_of_Elephant_Grass_Cenchrus_Purpureus_Schumach_Morrone_via_Activation_of_PI3K_AkT_Signaling_Pathway_Oxidative_Stress_Inhibition_and_Apoptosis_in_Wistar_Rats_pdf/19289231Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.3C3C4A3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphar.2022.845196.s001 |
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