دورية أكاديمية
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations
| العنوان: | Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations |
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| المؤلفون: | Banneau, G., Guedj, M., Macgrogan, G., de Mascarel, I., Velasco, V., Schiappa, R., Bonadona, Valérie, David, A., Dugast, C., Gilbert-Dussardier, B., Ingster, O., Vabres, P., Caux, F., de Reynies, A., Iggo, R., Sevenet, N., Bonnet, Fabrice, Longy, M. |
| المساهمون: | Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement LBBE, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1465-5411. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2010 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
| الوصف: | Introduction: Breast carcinoma is the main malignant tumor occurring in patients with Cowden disease, a cancer-prone syndrome caused by germline mutation of the tumor suppressor gene PTEN characterized by the occurrence throughout life of hyperplastic, hamartomatous and malignant growths affecting various organs. The absence of known histological features for breast cancer arising in a PTEN-mutant background prompted us to explore them for potential new markers.Methods: We first performed a microarray study of three tumors from patients with Cowden disease in the context of a transcriptomic study of 74 familial breast cancers. A subsequent histological and immunohistochemical study including 12 additional cases of Cowden disease breast carcinomas was performed to confirm the microarray data.Results: Unsupervised clustering of the 74 familial tumors followed the intrinsic gene classification of breast cancer except for a group of five tumors that included the three Cowden tumors. The gene expression profile of the Cowden tumors shows considerable overlap with that of a breast cancer subgroup known as molecular apocrine breast carcinoma, which is suspected to have increased androgenic signaling and shows frequent ERBB2 amplification in sporadic tumors. The histological and immunohistochemical study showed that several cases had apocrine histological features and expressed GGT1, which is a potential new marker for apocrine breast carcinoma.Conclusions: These data suggest that activation of the ERBB2-PI3K-AKT pathway by loss of PTEN at early stages of tumorigenesis promotes the formation of breast tumors with apocrine features. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00698403; https://hal.science/hal-00698403Test; PUBMEDCENTRAL: PMC2949656 |
| DOI: | 10.1186/bcr2626 |
| الإتاحة: | https://doi.org/10.1186/bcr2626Test https://hal.science/hal-00698403Test |
| رقم الانضمام: | edsbas.3BA84E3F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/bcr2626 |
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