دورية أكاديمية
Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohort
| العنوان: | Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohort |
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| المؤلفون: | Parodis, Ioannis, Lindblom, Julius, Barturen, Guillermo, Ortega-Castro, Rafaela, Cervera, Ricard, Pers, Jacques-Olivier, Genre, Fernanda, Hiepe, Falk, Gerosa, Maria, Kovács, László, De Langhe, Ellen, Piantoni, Silvia, Stummvoll, Georg, Vasconcelos, Carlos, Vigone, Barbara, Witte, Torsten, PRECISESADS Clinical Consortium, Alarcón-Riquelme, Marta E, Beretta, Lorenzo, Saraux, Alain, Devauchelle-Pensec, Valérie, Jousse-Joulin, Sandrine, Lauwerys, Bernard, Ducreux, Julie, Maudoux, Anne-Lise, Tavares, Ana, Neves, Esmeralda, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabe, Gonzalez-Gay Mantecón, Miguel Angel, Alonso, Ricardo Blanco, Martínez, Alfonso Corrales, Rodríguez-Pintó, Ignasi, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Angeles Aguirre-Zamorano, MA, Escudero-Contreras, Alejandro, Castro-Villegas, MA Carmen, Ortego, Norberto, Fernández Roldán, María Concepción, Raya, Enrique, Moleón, Inmaculada Jiménez, Ramon, Enrique de, Quintero, Isabel Díaz, Meroni, Pier Luigi, Schioppo, Tommaso, Artusi, Carolina, Chizzolini, Carlo, Zuber, Aleksandra, Wynar, Donatienne, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Thiel, Silvia, Maresca, Manuel Rodriguez, López-Berrio, Antonio, Aguilar-Quesada, Rocío, Navarro-Linares, Héctor |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2024 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Systemic lupus erythematosus |
| الوصف: | Objectives To unveil biological milieus underlying low disease activity (LDA) and remission versus active systemic lupus erythematosus (SLE). Methods We determined differentially expressed pathways (DEPs) in SLE patients from the PRECISESADS project (NTC02890121) stratified into patients fulfilling and not fulfilling the criteria of (1) Lupus LDA State (LLDAS), (2) Definitions of Remission in SLE remission, and (3) LLDAS exclusive of remission. Results We analysed data from 321 patients; 40.8% were in LLDAS, and 17.4% in DORIS remission. After exclusion of patients in remission, 28.3% were in LLDAS. Overall, 604 pathways differed significantly in LLDAS versus non-LLDAS patients with an false-discovery rate-corrected p (q)<0.05 and a robust effect size (dr)≥0.36. Accordingly, 288 pathways differed significantly between DORIS remitters and non-remitters (q<0.05 and dr≥0.36). DEPs yielded distinct molecular clusters characterised by differential serological, musculoskeletal, and renal activity. Analysis of partially overlapping samples showed no DEPs between LLDAS and DORIS remission. Drug repurposing potentiality for treating SLE was unveiled, as were important pathways underlying active SLE whose modulation could aid attainment of LLDAS/remission, including toll-like receptor (TLR) cascades, Bruton tyrosine kinase (BTK) activity, the cytotoxic T lymphocyte antigen 4 (CTLA-4)-related inhibitory signalling, and the nucleotide-binding oligomerization domain leucine-rich repeat-containing protein 3 (NLRP3) inflammasome pathway. Conclusions We demonstrated for the first time molecular signalling pathways distinguishing LLDAS/remission from active SLE. LLDAS/remission was associated with reversal of biological processes related to SLE pathogenesis and specific clinical manifestations. DEP clustering by remission better grouped patients compared with LLDAS, substantiating remission as the ultimate treatment goal in SLE; however, the lack of substantial pathway differentiation between the two states justifies LLDAS ... |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ard.bmj.com/cgi/content/short/83/7/889Test; http://dx.doi.org/10.1136/ard-2023-224795Test |
| DOI: | 10.1136/ard-2023-224795 |
| الإتاحة: | https://doi.org/10.1136/ard-2023-224795Test http://ard.bmj.com/cgi/content/short/83/7/889Test |
| حقوق: | Copyright (C) 2024, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.3B6EB76 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/ard-2023-224795 |
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