دورية أكاديمية
Independent validation of a pre-specified four-kallikrein marker model for prediction of adverse pathology and biochemical recurrence
| العنوان: | Independent validation of a pre-specified four-kallikrein marker model for prediction of adverse pathology and biochemical recurrence |
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| المؤلفون: | Rasmussen, Martin, Fredsøe, Jacob, Tin, Amy L., Vickers, Andrew J., Ulhøi, Benedicte, Borre, Michael, Eastham, James, Ehdaie, Behfar, Guillonneau, Bertrand, Laudone, Vincent, Scardino, Peter T., Touijer, Karim, Sørensen, Karina D., Lilja, Hans |
| المصدر: | British Journal of Cancer; 126(7), pp 1004-1009 (2022) ; ISSN: 0007-0920 |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2022 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Urology and Nephrology |
| الوصف: | Background: Accurate markers for prostate cancer (PC) risk stratification could aid decision-making for initial management strategies. The 4Kscore has an undefined role in predicting outcomes after radical prostatectomy (RP). Methods: We included 1476 patients with 4Kscore measured prior to RP at two institutions. The 4Kscore was assessed for prediction of adverse pathology at RP and biochemical recurrence (BCR) relative to a clinical model. We pre-specified that all analyses would be assessed in biopsy Grade Group 1 (GG1) or 2 (GG2) PC patients, separately. Results: The 4Kscore increased discrimination for adverse pathology in all patients (delta area under the receiver operative curve (AUC) 0.009, 95% confidence interval (CI) 0.002, 0.016; clinical model AUC 0.767), driven by GG1 (delta AUC 0.040, 95% CI 0.006, 0.073) rather than GG2 patients (delta AUC 0.005, 95% CI −0.012, 0.021). Adding 4Kscore improved prediction of BCR in all patients (delta C-index 0.014, 95% CI 0.007, 0.021; preop-BCR nomogram C-index 0.738), again with larger changes in GG1 than in GG2. Conclusions: This study validates prior investigations on the use of 4Kscore in men with biopsy-confirmed PC. Men with GG1 PC and a high 4Kscore may benefit from additional testing to guide treatment selection. Further research is warranted regarding the value of the 4Kscore in men with biopsy GG2 PC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/7630a940-d5b7-4ae9-aabc-61e77474b9b2Test; http://dx.doi.org/10.1038/s41416-021-01661-xTest; scopus:85121104641; pmid:34903844 |
| DOI: | 10.1038/s41416-021-01661-x |
| الإتاحة: | https://doi.org/10.1038/s41416-021-01661-xTest https://lup.lub.lu.se/record/7630a940-d5b7-4ae9-aabc-61e77474b9b2Test |
| رقم الانضمام: | edsbas.3B347CDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41416-021-01661-x |
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