مراجعة
Biomarkers of NRF2 signalling: Current status and future challenges
| العنوان: | Biomarkers of NRF2 signalling: Current status and future challenges |
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| المؤلفون: | Lastres-Becker, I., Morgenstern, C., Demirdögen, B.C., Costa, V.M., Daiber, A., Foresti, R., Motterlini, R. |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | NRF2, HMOX1 gene, human, nonhuman, NQO1 gene, Nrf2 signaling, oxidative stress, protein function, Review, SRXN1 gene, translational research, TXNRD1 gene, Biomarker, Oxidative stress response, Target genes, Transcription factor, biological marker, glutamate cysteine ligase, glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, heme oxygenase 1, nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, sulfiredoxin 1, thioredoxin reductase 1, transcription factor Nrf2, unclassified drug, body fluid, cell protection, GCLC gene |
| الوصف: | The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of NRF2 levels, the modulation of NRF2 activity is typically determined by measuring changes in the expression of one or more of its target genes and/or the associated protein products. However, there is a lack of consensus regarding the most relevant set of these genes/proteins that best represents NRF2 activity across cell types and species. We present the findings of a comprehensive literature search that according to stringent criteria identifies GCLC, GCLM, HMOX1, NQO1, SRXN1 and TXNRD1 as a robust panel of markers that are directly regulated by NRF2 in multiple cell and tissue types. We assess the relevance of these markers in clinically accessible biofluids and highlight future challenges in the development and use of NRF2 biomarkers in humans. © 2024 The Authors ; European Cooperation in Science and Technology, COST: CA20121; Medical Research Council, MRC: MR/X007413/1 |
| نوع الوثيقة: | review |
| اللغة: | English |
| تدمد: | 2213-2317 |
| العلاقة: | Redox Biology; DiÄŸer; https://doi.org/10.1016/j.redox.2024.103134Test; https://hdl.handle.net/20.500.11851/11559Test; 72; WOS:001233628200001; 2-s2.0-85190738421 |
| DOI: | 10.1016/j.redox.2024.103134 |
| الإتاحة: | https://doi.org/20.500.11851/1155910.1016/j.redox.2024.103134Test https://hdl.handle.net/20.500.11851/11559Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.3B1DDC08 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2024.103134 |