دورية أكاديمية
Genome-wide association study of blood lead shows multiple associations near ALAD
| العنوان: | Genome-wide association study of blood lead shows multiple associations near ALAD |
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| المؤلفون: | Warrington, Nicole M., Zhu, Gu, Dy, Veronica, Heath, Andrew C., Madden, Pamela A. F., Hemani, Gibran, Kemp, John P., Mcmahon, George, St Pourcain, Beate, Timpson, Nicholas J., Taylor, Caroline M., Golding, Jean, Lawlor, Debbie A., Steer, Colin, Montgomery, Grant W., Martin, Nicholas G., Smith, George Davey, Evans, David M., Whitfield, John B. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2015 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Biochemistry & Molecular Biology, Genetics & Heredity, 1311 Genetics, 1312 Molecular Biology, 2716 Genetics (clinical) |
| الوصف: | Exposure to high levels of environmental lead, or biomarker evidence of high body lead content, is associated with anaemia, developmental and neurological deficits in children, and increased mortality in adults. Adverse effects of lead still occur despite substantial reduction in environmental exposure. There is genetic variation between individuals in blood lead concentration but the polymorphisms contributing to this have not been defined. We measured blood or erythrocyte lead content, and carried out genome-wide association analysis, on population-based cohorts of adult volunteers from Australia and UK (N = 5433). Samples from Australia were collected in two studies, in 1993-1996 and 2002-2005 and from UK in 1991-1992. One locus, at ALAD on chromosome 9, showed consistent association with blood lead across countries and evidence for multiple independent allelic effects. The most significant single nucleotide polymorphism (SNP), rs1805313 (P = 3.91 × 10(-14) for lead concentration in a meta-analysis of all data), is known to have effects on ALAD expression in blood cells but other SNPs affecting ALAD expression did not affect blood lead. Variants at 12 other loci, including ABO, showed suggestive associations (5 × 10(-6) > P > 5 × 10(-8)). Identification of genetic polymorphisms affecting blood lead reinforces the view that genetic factors, as well as environmental ones, are important in determining blood lead levels. The ways in which ALAD variation affects lead uptake or distribution are still to be determined. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0964-6906 1460-2083 |
| العلاقة: | orcid:0000-0003-4195-775X; orcid:0000-0002-9105-2249; orcid:0000-0002-4140-8139; orcid:0000-0003-0663-4621; AA007535; AA013320; AA013321; AA013326; DA012854; Not set; 092731; WT088806; MC_UU_12013; FT130101709; MC_UU_12013/4; MC_UU_12013/5; MC_UU_12013/1; MC_PC_15018; MC_UU_12013/3 |
| الإتاحة: | https://doi.org/10.1093/hmg/ddv112Test https://espace.library.uq.edu.au/view/UQ:364784Test |
| رقم الانضمام: | edsbas.3AE67CD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09646906 14602083 |
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