دورية أكاديمية
Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies.
| العنوان: | Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. |
|---|---|
| المؤلفون: | Mak, Elijah, Reid, Robert I, Przybelski, Scott A, Lesnick, Timothy G, Schwarz, Christopher G, Senjem, Matthew L, Raghavan, Sheelakumari, Vemuri, Prashanthi, Jack, Clifford R, Min, Hoon Ki, Jain, Manoj K, Miyagawa, Toji, Forsberg, Leah K, Fields, Julie A, Savica, Rodolfo, Graff-Radford, Jonathan, Jones, David T, Botha, Hugo, St Louis, Erik K, Knopman, David S, Ramanan, Vijay K, Dickson, Dennis W, Graff-Radford, Neill R, Ferman, Tanis J, Petersen, Ronald C, Lowe, Val J, Boeve, Bradley F, O'Brien, John T, Kantarci, Kejal |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1038/s41531-024-00684-4 NPJ Parkinsons Dis |
| سنة النشر: | 2024 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | 32 Biomedical and Clinical Sciences, 5202 Biological Psychology, 5204 Cognitive and Computational Psychology, 3209 Neurosciences, 52 Psychology, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Alzheimer's Disease, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Aging, Dementia, Physical Injury - Accidents and Adverse Effects, Clinical Research, Acquired Cognitive Impairment, Lewy Body Dementia, 2 Aetiology, 2.1 Biological and endogenous factors, Neurological |
| الوصف: | Funder: National Institute of Health, R01 AG40042 ; Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer's disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help elucidate the biological underpinnings of white matter injury in individuals with DLB. In this study, diffusion tensor imaging (DTI) and NODDI metrics were compared in 45 patients within the dementia with Lewy bodies spectrum (mild cognitive impairment with Lewy bodies (n = 13) and probable dementia with Lewy bodies (n = 32)) against 45 matched controls using conditional logistic models. We evaluated the associations of tau and amyloid-β with DTI and NODDI parameters and examined the correlations of AD-related white matter injury with Clinical Dementia Rating (CDR). Structural equation models (SEM) explored relationships among age, APOE ε4, amyloid-β, tau, and white matter injury. The DLB spectrum group exhibited widespread white matter abnormalities, including reduced fractional anisotropy, increased mean diffusivity, and decreased neurite density index. Tau was significantly associated with limbic and temporal white matter injury, which was, in turn, associated with worse CDR. SEM revealed that amyloid-β exerted indirect effects on white matter injury through tau. We observed widespread disruptions in white matter tracts in DLB that were not attributed to AD pathologies, likely due to α-synuclein-related injury. However, a fraction of the white matter injury could be attributed to AD pathology. Our findings underscore the impact of AD pathology on white matter integrity in DLB and highlight the utility of NODDI in elucidating the biological basis of white matter injury in DLB. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/366670Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/366670Test |
| رقم الانضمام: | edsbas.3ADEF960 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |