دورية أكاديمية
Analysis of treatment sequence and outcomes in patients with relapsed malignant peripheral nerve sheath tumors
| العنوان: | Analysis of treatment sequence and outcomes in patients with relapsed malignant peripheral nerve sheath tumors |
|---|---|
| المؤلفون: | Zhang, Lindy, Lemberg, Kathryn M, Calizo, Ana, Varadhan, Ravi, Siegel, Alan H, Meyer, Christian F, Blakeley, Jaishri O, Pratilas, Christine A |
| المصدر: | Neuro-Oncology Advances ; volume 5, issue 1 ; ISSN 2632-2498 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Surgery, Oncology, Neurology (clinical) |
| الوصف: | Background Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas originating from cellular components within the nerve sheath. The incidence of MPNST is highest in people with neurofibromatosis type 1 (NF1), and MPNST is the leading cause of death for these individuals. Complete surgical resection is the only curative therapeutic option, but is often unfeasible due to tumor location, size, or presence of metastases. Evidence-based choices of chemotherapy for recurrent/refractory MPNST remain elusive. To address this gap, we conducted a retrospective analysis of our institutional experience in treating patients with relapsed MPNST in order to describe patient outcomes related to salvage regimens. Methods We conducted a retrospective electronic health record analysis of patients with MPNST who were treated at Johns Hopkins Hospital from January 2010 to June 2021. We calculated time to progression (TTP) based on salvage chemotherapy regimens. Results Sixty-five patients were included in the analysis. Upfront therapy included single or combined modalities of surgery, chemotherapy, or radiotherapy. Forty-eight patients received at least 1 line of chemotherapy, which included 23 different regimens (excluding active clinical studies). Most patients (n = 42, 87.5%) received a combination of doxorubicin, ifosfamide, or etoposide as first-line chemotherapy. Salvage chemotherapy regimens and their TTP varied greatly, with irinotecan/temozolomide-based regimens having the longest average TTP (255.5 days, among 4 patients). Conclusions Patients with advanced or metastatic MPNST often succumb to their disease despite multiple lines of therapy. These data may be used as comparative information in decision-making for future patients and clinical trials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/noajnl/vdad156 |
| DOI: | 10.1093/noajnl/vdad156/53975956/vdad156.pdf |
| الإتاحة: | https://doi.org/10.1093/noajnl/vdad156Test https://academic.oup.com/noa/article-pdf/5/1/vdad156/54715972/vdad156.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.3A8E3DDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/noajnl/vdad156 |
|---|