دورية أكاديمية
Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
| العنوان: | Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain |
|---|---|
| المؤلفون: | Jové Font, Mariona, Mota Martorell, Natàlia, Obis Monné, Èlia, Sol, Joaquim, Martín Garí, Meritxell, Ferrer, Isidre, Portero Otín, Manuel, Pamplona Gras, Reinald |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Antioxidants, Cholesterol, Docosahexaenoic acid, Fatty acids, Lipidomics |
| الوصف: | It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. However, it is also evident that human neurons, although they are post-mitotic cells, survive throughout an entire lifetime. Therefore, to reduce or avoid the impact of oxidative stress on neuron functionality and survival, they must have evolved several adaptive mechanisms to cope with the deleterious effects of oxidative stress. Several of these antioxidant features are derived from lipid adaptations. At least six lipid adaptations against oxidative challenge in the healthy human brain can be discerned. In this work, we explore the idea that neurons and, by extension, the human brain is endowed with an important arsenal of non-pro-oxidant and antioxidant measures to preserve neuronal function, refuting part of the initial premise. ; Research by the authors was supported by the Spanish Ministry of Science, Innovation, and Universities (grant RTI2018-099200-B-I00), the Diputació de Lleida (PP10605-PIRS2021), the Generalitat of Catalonia: Agency for Management of University and Research Grants (2017SGR696), and Department of Health (SLT002/16/00250) to RP. This study has been co-financed by FEDER funds from the European Union (“A way to build Europe”). IRBLleida is a CERCA Programme/Generalitat of Catalonia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-3921 |
| العلاقة: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/; Reproducció del document publicat a https://doi.org/10.3390/antiox12010177Test; Antioxidants, 2023, vol. 12, núm. 1, 177; https://doi.org/10.3390/antiox12010177Test; https://repositori.udl.cat/handle/10459.1/464456Test |
| DOI: | 10.3390/antiox12010177 |
| الإتاحة: | https://doi.org/10.3390/antiox12010177Test https://repositori.udl.cat/handle/10459.1/464456Test |
| حقوق: | cc-by (c) Mariona Jové et al., 2023 ; Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.3A891C8B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20763921 |
|---|---|
| DOI: | 10.3390/antiox12010177 |