دورية أكاديمية
Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
| العنوان: | Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19 |
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| المؤلفون: | Scoccia A., Gallone G., Cereda A., Palmisano A., Vignale D., Leone R., Nicoletti V., Gnasso C., Monello A., Khokhar A., Sticchi A., Biagi A., Tacchetti C., Campo G., Rapezzi C., Ponticelli F., Danzi G. B., Loffi M., Pontone G., Andreini D., Casella G., Iannopollo G., Ippolito D., Bellani G., Patelli G., Besana F., Costa C., Vignali L., Benatti G., Iannaccone M., Vaudano P. G., Pacielli A., De Carlini C. C., Maggiolini S., Bonaffini P. A., Senni M., Scarnecchia E., Anastasio F., Colombo A., Ferrari R., Esposito A., Giannini F., Toselli M. |
| المساهمون: | Scoccia, A., Gallone, G., Cereda, A., Palmisano, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Khokhar, A., Sticchi, A., Biagi, A., Tacchetti, C., Campo, G., Rapezzi, C., Ponticelli, F., Danzi, G. B., Loffi, M., Pontone, G., Andreini, D., Casella, G., Iannopollo, G., Ippolito, D., Bellani, G., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Iannaccone, M., Vaudano, P. G., Pacielli, A., De Carlini, C. C., Maggiolini, S., Bonaffini, P. A., Senni, M., Scarnecchia, E., Anastasio, F., Colombo, A., Ferrari, R., Esposito, A., Giannini, F., Toselli, M. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | COVID-19, Coronary artery disease, Atherosclerosis, Agatston score, Coronary artery calcifications, Calcium score, In-hospital mortality |
| الوصف: | Background and aims: The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. Methods: SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) “clinical CAD” (prior revascularization history), (b) “subclinical CAD” (CAC >0), (c) “No CAD” (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). Results: Amongst 1625 patients (male 67.2%, median age 69 [interquartile range 58–77] years), 31%, 57.8% and 11.1% had no, subclinical and clinical CAD, respectively. Increasing rates of in-hospital mortality (11.3% vs. 27.3% vs. 39.8%, p < 0.001) and MI/CVA events (2.3% vs. 3.8% vs. 11.9%, p < 0.001) were observed for patients with no CAD vs. subclinical CAD vs clinical CAD, respectively. The association with in-hospital mortality was independent of in-study outcome predictors (age, peripheral artery disease, active cancer, hemoglobin, C-reactive protein, LDH, aerated lung volume): subclinical CAD vs. No CAD: adjusted hazard ratio (adj-HR) 2.86 (95% confidence interval [CI] 1.14–7.17, p=0.025); clinical CAD vs. No CAD: adj-HR 3.74 (95% CI 1.21–11.60, p=0.022). Among patients with subclinical CAD, increasing CAC burden was associated with higher rates of in-hospital mortality (20.5% vs. 27.9% vs. 38.7% for patients with CAC score thresholds≤100, 101–400 and > 400, respectively, p < 0.001). The adj-HR per 50 points increase in CAC score 1.007 (95%CI 1.001–1.013, p=0.016). ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33883086; info:eu-repo/semantics/altIdentifier/wos/WOS:000668002800005; volume:328; firstpage:136; lastpage:143; numberofpages:8; journal:ATHEROSCLEROSIS; https://hdl.handle.net/11392/2472204Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104463785; https://www.atherosclerosis-journal.com/article/S0021-9150Test(21)00165-9/fulltext |
| DOI: | 10.1016/j.atherosclerosis.2021.03.041 |
| الإتاحة: | https://doi.org/10.1016/j.atherosclerosis.2021.03.041Test https://hdl.handle.net/11392/2472204Test https://www.atherosclerosis-journal.com/article/S0021-9150Test(21)00165-9/fulltext |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3A5C53D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.atherosclerosis.2021.03.041 |
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