التفاصيل البيبلوغرافية
| العنوان: |
The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases |
| المؤلفون: |
Alenius, Harri, Sinkko, Hanna, Moitinho-Silva, Lucas, Rodriguez, Elke, Broderick, Conor, Alexander, Helen, Reiger, Matthias, Hjelmso, Mathis Hjort, Fyhrquist, Nanna, Olah, Peter, Bryce, Paul, Smith, Catherine, Koning, Frits, Eyerich, Kilian, Greco, Dario, van den Bogaard, Ellen H., Neumann, Avidan U., Traidl-Hoffmann, Claudia, Homey, Bernhard, Flohr, Carsten, Bonnelykke, Klaus, Stokholm, Jakob, Weidinger, Stephan |
| المساهمون: |
HUMI - Human Microbiome Research, Faculty of Medicine, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
atopic dermatitis, biomarkers, microbiome, psoriasis, STAPHYLOCOCCUS-AUREUS COLONIZATION, CHRONIC PLAQUE PSORIASIS, ATOPIC-DERMATITIS, GUT MICROBIOTA, GLOBAL BURDEN, YOUNG INFANT, EARLY-LIFE, ECZEMA, ASSOCIATION, PREVALENCE, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: |
The two most common chronic inflammatory skin diseases are atopic dermatitis (AD) and psoriasis. The underpinnings of the remarkable degree of clinical heterogeneity of AD and psoriasis are poorly understood and, as a consequence, disease onset and progression are unpredictable and the optimal type and time point for intervention are as yet unknown. The BIOMAP project is the first IMI (Innovative Medicines Initiative) project dedicated to investigating the causes and mechanisms of AD and psoriasis and to identify potential biomarkers responsible for the variation in disease outcome. The consortium includes 7 large pharmaceutical companies and 25 non-industry partners including academia. Since there is mounting evidence supporting an important role for microbial exposures and our microbiota as factors mediating immune polarization and AD and psoriasis pathogenesis, an entire work package is dedicated to the investigation of skin and gut microbiome linked to AD or psoriasis. The large collaborative BIOMAP project will enable the integration of patient cohorts, data and knowledge in unprecedented proportions. The project has a unique opportunity with a potential to bridge and fill the gaps between current problems and solutions. This review highlights the power and potential of the BIOMAP project in the investigation of microbe-host interplay in AD and psoriasis. ; Peer reviewed |
| نوع الوثيقة: |
review |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
The research has received funding from the FP7 (MAARS-Grant 261366) and IMI2 (BIOMAP-Grant 821511).; Alenius , H , Sinkko , H , Moitinho-Silva , L , Rodriguez , E , Broderick , C , Alexander , H , Reiger , M , Hjelmso , M H , Fyhrquist , N , Olah , P , Bryce , P , Smith , C , Koning , F , Eyerich , K , Greco , D , van den Bogaard , E H , Neumann , A U , Traidl-Hoffmann , C , Homey , B , Flohr , C , Bonnelykke , K , Stokholm , J & Weidinger , S 2021 , ' The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases ' , Experimental Dermatology , vol. 30 , no. 10 , pp. 1517-1531 . https://doi.org/10.1111/exd.14446Test; ORCID: /0000-0001-9195-9003/work/101176795; 5880114c-1fab-4dcf-8a13-e47f750bb954; http://hdl.handle.net/10138/335076Test; 000687548700001 |
| الإتاحة: |
http://hdl.handle.net/10138/335076Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.3A206613 |
| قاعدة البيانات: |
BASE |
