دورية أكاديمية
Expression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
| العنوان: | Expression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis |
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| المؤلفون: | Chua, DTT, Zhang, WB, Zheng, LW, Cheung, LK |
| بيانات النشر: | //www.elsevier.com/locate/joms United States |
| سنة النشر: | 2011 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Osteogenesis, Distraction, Bone Morphogenetic Proteins - *analysis - radiation effects, Vascular Endothelial Growth Factor A - analysis - radiation effects, Fibroblast Growth Factor 2 - *analysis - radiation effects, Mandible - *radiation effects - surgery |
| الوصف: | Purpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. © 2011 American Association of Oral and Maxillofacial Surgeons. ; link_to_subscribed_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-297138-6 0-00-297138-0 |
| تدمد: | 0278-2391 |
| العلاقة: | Journal of Oral and Maxillofacial Surgery; http://www.scopus.com/mlt/select.url?eid=2-s2.0-80054939289&selection=ref&src=s&origin=recordpageTest; Journal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 11, p. 2860-2871; 2871; 210168; 188020; WOS:000297138000033; 11; eid_2-s2.0-80054939289; 2860; http://hdl.handle.net/10722/134985Test; 69 |
| DOI: | 10.1016/j.joms.2010.12.037 |
| الإتاحة: | https://doi.org/10.1016/j.joms.2010.12.037Test http://hdl.handle.net/10722/134985Test |
| رقم الانضمام: | edsbas.3A1EB641 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780002971386 0002971380 |
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| تدمد: | 02782391 |
| DOI: | 10.1016/j.joms.2010.12.037 |