دورية أكاديمية
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology
| العنوان: | Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology |
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| المؤلفون: | Ide, M, Ohnishi, T, Toyoshima, M, Balan, S, Maekawa, M, Shimamoto-Mitsuyama, C, Iwayama, Y, Ohba, H, Watanabe, A, Ishii, T, Shibuya, N, Kimura, Y, Hisano, Y, Murata, Y, Hara, T, Morikawa, M, Hashimoto, K, Nozaki, Y, Toyota, T, Wada, Y, Tanaka, Y, Kato, T, Nishi, A, Fujisawa, S, Okano, H, Itokawa, M, Hirokawa, N, Kunii, Y, Kakita, A, Yabe, H, Iwamoto, K, Meno, K, Katagiri, T, Dean, B, Uchida, K, Kimura, H, Yoshikawa, T |
| بيانات النشر: | WILEY |
| سنة النشر: | 2019 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H2 S)/polysulfide-producing enzyme, and greater sulfide deposition in C3H than B6 mice. Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Analysis of human samples demonstrated that the H2 S/polysulfides production system is upregulated in schizophrenia. Mechanistically, the Mpst-Tg brain revealed dampened energy metabolism, while maternal immune activation model mice showed upregulation of genes for H2 S/polysulfides production along with typical antioxidative genes, partly via epigenetic modifications. These results suggest that inflammatory/oxidative insults in early brain development result in upregulated H2 S/polysulfides production as an antioxidative response, which in turn cause deficits in bioenergetic processes. Collectively, this study presents a novel aspect of the neurodevelopmental theory for schizophrenia, unraveling a role of excess H2 S/polysulfides production. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1757-4676 1757-4684 |
| العلاقة: | Ide, M., Ohnishi, T., Toyoshima, M., Balan, S., Maekawa, M., Shimamoto-Mitsuyama, C., Iwayama, Y., Ohba, H., Watanabe, A., Ishii, T., Shibuya, N., Kimura, Y., Hisano, Y., Murata, Y., Hara, T., Morikawa, M., Hashimoto, K., Nozaki, Y., Toyota, T. ,. Yoshikawa, T. (2019). Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO MOLECULAR MEDICINE, 11 (12), https://doi.org/10.15252/emmm.201910695Test.; http://hdl.handle.net/11343/247092Test |
| الإتاحة: | https://doi.org/10.15252/emmm.201910695Test http://hdl.handle.net/11343/247092Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.39FB4355 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17574676 17574684 |
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