دورية أكاديمية
Nationwide practice in CT-based preoperative staging of colon cancer and concordance with definitive pathology
| العنوان: | Nationwide practice in CT-based preoperative staging of colon cancer and concordance with definitive pathology |
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| المؤلفون: | Sikkenk, Daan J, Sijmons, Julie M L, Burghgraef, Thijs A, Asaggau, Ilias, Vos, Annelotte, da Costa, David W, Somers, Inne, Verheijen, Paul M, Dekker, Jan-Willem T, Nagengast, Wouter B, Tanis, Pieter J, Consten, Esther C J |
| المصدر: | Sikkenk , D J , Sijmons , J M L , Burghgraef , T A , Asaggau , I , Vos , A , da Costa , D W , Somers , I , Verheijen , P M , Dekker , J-W T , Nagengast , W B , Tanis , P J & Consten , E C J 2023 , ' Nationwide practice in CT-based preoperative staging of colon cancer and concordance with definitive pathology ' , European Journal of Surgical Oncology , vol. 49 , no. 10 , 106941 . https://doi.org/10.1016/j.ejso.2023.05.016Test |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| الوصف: | INTRODUCTION: In an era of exploring patient-tailored treatment options for colon cancer, preoperative staging is increasingly important. This study aimed to evaluate completeness and reliability of CT-based preoperative locoregional colon cancer staging in Dutch hospitals. MATERIALS AND METHODS: Patients who underwent elective oncological resection of colon cancer without neoadjuvant treatment in 77 Dutch hospitals were evaluated between 2011 and 2021. Completeness of T-stage was calculated for individual hospitals and stratified based on a 60% cut-off. Concordance between routine CT-based preoperative locoregional staging (cTN) and definitive pathological staging (pTN) was examined. RESULTS: A total of 59,558 patients were included with an average completeness of 43.4% and 53.4% for T and N-stage, respectively. Completeness of T-stage improved from 4.9% in 2011-2014 to 74.4% in 2019-2021. Median completeness for individual hospitals was 53.9% (IQR 27.3-80.5%) and were not significantly different between low and high-volume hospitals. Sensitivity and specificity for T3-4 tumours were relatively low: 75.1% and 76.0%, respectively. cT1-2 tumours were frequently understaged based on a low negative predictive value of 56.8%. Distinction of cT4 and cN2 disease had a high specificity (>95%), but a very low sensitivity (<50%). Positive predictive values of <60% indicated that cT4 and cN1-2 were often overstaged. Completeness and time period did not influence reliability of staging. CONCLUSION: Completeness of locoregional staging of colon cancer improved during recent years and varied between hospitals independently from case volume. Discriminating cT1-2 from cT3-4 tumours resulted in substantial understaging and overstaging, additionally cT4 and cN1-2 were overstaged in >40% of cases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/84f11ffe-9430-4bd1-a15b-cd547576cb13Test |
| DOI: | 10.1016/j.ejso.2023.05.016 |
| الإتاحة: | https://doi.org/10.1016/j.ejso.2023.05.016Test https://hdl.handle.net/11370/84f11ffe-9430-4bd1-a15b-cd547576cb13Test https://research.rug.nl/en/publications/84f11ffe-9430-4bd1-a15b-cd547576cb13Test https://pure.rug.nl/ws/files/886193209/1-s2.0-S0748798323005103-main.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.39C05216 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejso.2023.05.016 |
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