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Cancer mortality and competing causes of death in older adults with cancer: A prospective, multicentre cohort study ( ELCAPA ‐19)

التفاصيل البيبلوغرافية
العنوان: Cancer mortality and competing causes of death in older adults with cancer: A prospective, multicentre cohort study ( ELCAPA ‐19)
المؤلفون: Assouan, Déborah, Paillaud, Elena, Caillet, Philippe, Broussier, Amaury, Kempf, Emmanuelle, Frelaut, Maxime, Brain, Etienne, Lorisson, Emmanuelle, Chambraud, Clelia, Bastuji‐garin, Sylvie, Hanon, Olivier, Canouï‐poitrine, Florence, Laurent, Marie, Martinez‐tapia, Claudia
المساهمون: CHU Amiens-Picardie, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" Créteil (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Cancer Research and Personalized Medicine - CARPEM Paris (SIRIC CARPEM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer (INCa), Hôpital Henri Mondor, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Groupe Henri Mondor-Albert Chenevier, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, Institut Gustave Roussy (IGR), Institut Curie Paris, Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), AP-HP - Hôpital Cochin Broca Hôtel Dieu Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
المصدر: ISSN: 2045-7634.
بيانات النشر: HAL CCSD
Wiley
سنة النشر: 2023
مصطلحات موضوعية: cancer, cause of death, geriatric assessment, ADL, activities of daily living BMI, body mass index CIRS-G, Cumulative Illness Rating Scale for geriatrics ECOG-PS, Eastern Cooperative IQR, interquartile range SD, standard deviation TGUG, Timed-Get-, activities of daily living, BMI, body mass index, CIRS-G, Cumulative Illness Rating Scale for geriatrics, ECOG-PS, interquartile range, SD, standard deviation, TGUG, [SDV.CAN]Life Sciences [q-bio]/Cancer, [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an], [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
الوصف: International audience ; Abstract Background In older patients with cancer, comorbidities compete with cancer for cause of death. The objectives were to evaluate cancer mortality and factors associated, according to metastatic status. Methods Between 2007 and 2014, patients with cancer aged ≥70 referred for pre‐therapeutic geriatric assessment (GA) were included through the ELCAPA prospective cohort study. The underlying cause of death was defined according to the International Classification of Diseases, 10th Revision. The World Health Organisation definition was used to categorise the cause of death as cancer versus another disease (e.g. cardiovascular disease, infectious disease, etc.) Competing risk models were used. Results Mean (SD) age of the 1445 included patients was 80.2 (5.8) and 48% were women. Most common tumour sites were colorectal (19%), breast (17%) and urinary (15%); 773 patients (49%) had metastases. After a 34‐month median follow‐up, 706 cancer deaths were observed among 843 deaths. The 6‐month and 3‐year cancer mortality rates (95% CI) were 12% (9–15) and 34% (29–38) for non‐metastatic patients and 43% (39–47) and 79% (75–82) for metastatic patients, respectively. Dependency in activities of daily living and comorbidities were associated with 6‐month and 3‐year cancer mortality in non‐metastatic (adjusted subhazard ratio [aSHR] = 1.68 [0.99–2.85] and 1.69 [1.16–2.45]; and 1.98 [1.08–3.63] and 3.38 [1.47–7.76], respectively) and metastatic patients (aSHR = 2.81 [2.01–3.93] and 2.95 [2.14–4.07]; and 1.63 [1.18–2.25] and 2.06 [1.39–3.05], respectively). Impaired Timed‐Get‐Up‐and‐Go test was associated with 6‐month and 3‐year cancer mortality in metastatic patients (aSHR = 1.5 [1.06–2.12] and 1.38 [1.06–1.81], respectively). Obesity was negatively associated with 3‐year cancer death in non‐metastatic (aSHR = 0.53 [0.29–0.97]) and metastatic patients (aSHR = 0.71 [0.51–1.00]). Conclusions The majority of older adults with cancer referred for pre‐therapeutic GA die from cancer. Geriatric ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37937731; hal-04604607; https://hal.science/hal-04604607Test; https://hal.science/hal-04604607/documentTest; https://hal.science/hal-04604607/file/CAM4-12-20940.pdfTest; PUBMED: 37937731; PUBMEDCENTRAL: PMC10709739
DOI: 10.1002/cam4.6639
الإتاحة: https://doi.org/10.1002/cam4.6639Test
https://hal.science/hal-04604607Test
https://hal.science/hal-04604607/documentTest
https://hal.science/hal-04604607/file/CAM4-12-20940.pdfTest
حقوق: info:eu-repo/semantics/OpenAccess
رقم الانضمام: edsbas.398EAF17
قاعدة البيانات: BASE
الوصف
DOI:10.1002/cam4.6639